AIMS/HYPOTHESIS: Insulin resistance and related metabolic disturbances are more common among Asian Indians than European whites. Little is known about the heritability of insulin resistance traits in Asian Indians. Our objective was to estimate heritabilities and genetic correlations in Asian Indian families. METHODS: Phenotypic data were assembled for 181 UK Asian Indian probands with premature CHD, and their 1,454 first-, second- and third-degree relatives. We calculated (narrow-sense) heritabilities and genetic correlations for insulin resistance traits, and common environmental effects using all study participants and a multivariate model. The analysis was repeated in a subsample consisting of individuals not on drug therapy. RESULTS: Heritability estimates (SE) for individuals not on drug therapy were: BMI 0.31 (0.04), WHR 0.27 (0.04), systolic BP 0.29 (0.03), triacylglycerol 0.40 (0.04), HDL-cholesterol 0.53 (0.04), glucose 0.37 (0.03), HOMA of insulin resistance (HOMA-IR) 0.22 (0.04), and HbA(1c) 0.60 (0.04). We observed many significant genetic correlations between the traits, in particular between HOMA-IR and BMI. Heritability estimates were lower for all phenotypes when analysed among all participants. CONCLUSIONS/ INTERPRETATION: Genetic factors contribute to a significant proportion of the total variance in insulin resistance and related metabolic disturbances in Asian Indian CHD families.
AIMS/HYPOTHESIS: Insulin resistance and related metabolic disturbances are more common among Asian Indians than European whites. Little is known about the heritability of insulin resistance traits in Asian Indians. Our objective was to estimate heritabilities and genetic correlations in Asian Indian families. METHODS: Phenotypic data were assembled for 181 UK Asian Indian probands with premature CHD, and their 1,454 first-, second- and third-degree relatives. We calculated (narrow-sense) heritabilities and genetic correlations for insulin resistance traits, and common environmental effects using all study participants and a multivariate model. The analysis was repeated in a subsample consisting of individuals not on drug therapy. RESULTS: Heritability estimates (SE) for individuals not on drug therapy were: BMI 0.31 (0.04), WHR 0.27 (0.04), systolic BP 0.29 (0.03), triacylglycerol 0.40 (0.04), HDL-cholesterol 0.53 (0.04), glucose 0.37 (0.03), HOMA of insulin resistance (HOMA-IR) 0.22 (0.04), and HbA(1c) 0.60 (0.04). We observed many significant genetic correlations between the traits, in particular between HOMA-IR and BMI. Heritability estimates were lower for all phenotypes when analysed among all participants. CONCLUSIONS/ INTERPRETATION: Genetic factors contribute to a significant proportion of the total variance in insulin resistance and related metabolic disturbances in Asian Indian CHD families.
Authors: John C Chambers; Paul Elliott; Delilah Zabaneh; Weihua Zhang; Yun Li; Philippe Froguel; David Balding; James Scott; Jaspal S Kooner Journal: Nat Genet Date: 2008-05-04 Impact factor: 38.330
Authors: Cara L Carty; Samsiddhi Bhattacharjee; Jeff Haessler; Iona Cheng; Lucia A Hindorff; Vanita Aroda; Christopher S Carlson; Chun-Nan Hsu; Lynne Wilkens; Simin Liu; Elizabeth Selvin; Rebecca Jackson; Kari E North; Ulrike Peters; James S Pankow; Nilanjan Chatterjee; Charles Kooperberg Journal: Circ Cardiovasc Genet Date: 2014-07-14
Authors: Matthew D Barberio; Kim M Huffman; Mamta Giri; Eric P Hoffman; William E Kraus; Monica J Hubal Journal: Med Sci Sports Exerc Date: 2016-12 Impact factor: 5.411
Authors: Cathy E Elks; Marcel den Hoed; Jing Hua Zhao; Stephen J Sharp; Nicholas J Wareham; Ruth J F Loos; Ken K Ong Journal: Front Endocrinol (Lausanne) Date: 2012-02-28 Impact factor: 5.555
Authors: Timothy R Braun; Latonya F Been; Akhil Singhal; Jacob Worsham; Sarju Ralhan; Gurpreet S Wander; John C Chambers; Jaspal S Kooner; Christopher E Aston; Dharambir K Sanghera Journal: PLoS One Date: 2012-05-18 Impact factor: 3.240