| Literature DB >> 19762238 |
Christopher J Burns1, David G Bourke, Laura Andrau, Xianyong Bu, Susan A Charman, Andrew C Donohue, Emmanuelle Fantino, Michelle Farrugia, John T Feutrill, Max Joffe, Marcel R Kling, Margarita Kurek, Tracy L Nero, Thao Nguyen, James T Palmer, Ian Phillips, David M Shackleford, Harrison Sikanyika, Michelle Styles, Stephen Su, Herbert Treutlein, Jun Zeng, Andrew F Wilks.
Abstract
A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported.Entities:
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Year: 2009 PMID： 19762238 DOI： 10.1016/j.bmcl.2009.08.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823