| Literature DB >> 19762234 |
Tomoharu Tsukada1, Mizuki Takahashi, Toshiyasu Takemoto, Osamu Kanno, Takahiro Yamane, Sayako Kawamura, Takahide Nishi.
Abstract
With the aim of discovering a novel class of fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of compounds based on tricyclic scaffolds was synthesized. Extensive SAR studies led to the finding of 8l with an IC50 value of 0.013 microM against human FBPase. An X-ray crystallographic study revealed that 8l bound at AMP binding sites of human liver FBPase with hydrogen bonding interactions similar to AMP.Entities:
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Year: 2009 PMID： 19762234 DOI： 10.1016/j.bmcl.2009.08.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823