| Literature DB >> 19761692 |
Y-G Yang1, D-M Jiang, Z-X Quan, Y-S Ou.
Abstract
Traumatic brain injury is often associated with acute spinal cord injury (ASCI). Insulin and chondroitinase ABC (ChABC) are both therapeutically effective, but the combined therapeutic effect of insulin and ChABC is still not clear. A combination of insulin and ChABC were used to treat a rat model of ASCI. This combination therapy prevented neuronal cell death by improving motor function, increasing cell growth and inhibiting cell apoptosis in ASCI rats. Expression of growth-associated protein 43, a marker of axonal re-growth, increased after combined treatment with insulin and ChABC. These results may provide a basis for a future method of treating ASCI.Entities:
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Year: 2009 PMID： 19761692 DOI： 10.1177/147323000903700414
Source DB: PubMed Journal: J Int Med Res ISSN： 0300-0605 Impact factor: 1.671