| Literature DB >> 19761352 |
O Tyapkina1, E Volkov, L Nurullin, B Shenkman, I Kozlovskaya, E Nikolsky, F Vyskocil.
Abstract
Antiorthostatic hindlimb suspension (unloading) decreased the resting membrane potential (RMP) of skeletal muscle fibers in fast extensor digitorum longus (EDL) and slow soleus (SOL) muscle of the rat by about 10% within 7 days and more. Inactivation of the membrane Na+,K+-pump by ouabain brought about similar depolarization as unloading. The increased sodium permeability of the membrane was excluded as the major cause of this depolarization by experiments in which TRIS was substituted for Na+ in the medium. On the other hand, the decrease in the electrogenic participation of the Na+,K+-pump is apparently one of the causes of RMP decrease during hypogravity, in EDL muscle in particular.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19761352
Source DB: PubMed Journal: Physiol Res ISSN： 0862-8408 Impact factor: 1.881