BACKGROUND: The pacing site has been shown to influence functional improvement with cardiac resynchronization therapy. We evaluated the effects of the pacing site on left ventricular (LV) function in an animal model. METHODS AND RESULTS: Equilibrium radionuclide angiography was acquired in sinus rhythm (NSR) and with ventricular pacing, from three pacing sites in seven normal and eight infarcted dogs. QRS duration, electrical activation pattern, wall motion, LV ejection fraction (EF), synchrony of ventricular contraction, and mean arterial pressure (MAP), were related to the pacing site and infarct size, during each of 120 episodes. Little changed during pacing in normals. In infarcted dogs, LV wall motion, and synchrony worsened, LVEF and MAP often fell. These changes related to altered activation patterns which were influenced by the pacing site but were not related to infarct size. CONCLUSIONS: Hemodynamic and functional LV changes after infarction were found to vary with the pacing site and associated conduction and synchrony.
BACKGROUND: The pacing site has been shown to influence functional improvement with cardiac resynchronization therapy. We evaluated the effects of the pacing site on left ventricular (LV) function in an animal model. METHODS AND RESULTS: Equilibrium radionuclide angiography was acquired in sinus rhythm (NSR) and with ventricular pacing, from three pacing sites in seven normal and eight infarcteddogs. QRS duration, electrical activation pattern, wall motion, LV ejection fraction (EF), synchrony of ventricular contraction, and mean arterial pressure (MAP), were related to the pacing site and infarct size, during each of 120 episodes. Little changed during pacing in normals. In infarcteddogs, LV wall motion, and synchrony worsened, LVEF and MAP often fell. These changes related to altered activation patterns which were influenced by the pacing site but were not related to infarct size. CONCLUSIONS: Hemodynamic and functional LV changes after infarction were found to vary with the pacing site and associated conduction and synchrony.
Authors: Claudia Ypenburg; Martin J Schalij; Gabe B Bleeker; Paul Steendijk; Eric Boersma; Petra Dibbets-Schneider; Marcel P M Stokkel; Ernst E van der Wall; Jeroen J Bax Journal: Eur Heart J Date: 2006-11-22 Impact factor: 29.983
Authors: Jeroen J Bax; Gabe B Bleeker; Thomas H Marwick; Sander G Molhoek; Eric Boersma; Paul Steendijk; Ernst E van der Wall; Martin J Schalij Journal: J Am Coll Cardiol Date: 2004-11-02 Impact factor: 24.094
Authors: Maria Vittoria Pitzalis; Massimo Iacoviello; Roberta Romito; Pietro Guida; Elisabetta De Tommasi; Giovanni Luzzi; Matteo Anaclerio; Cinzia Forleo; Paolo Rizzon Journal: J Am Coll Cardiol Date: 2005-01-04 Impact factor: 24.094
Authors: John G F Cleland; Jean-Claude Daubert; Erland Erdmann; Nick Freemantle; Daniel Gras; Lukas Kappenberger; Luigi Tavazzi Journal: N Engl J Med Date: 2005-03-07 Impact factor: 91.245
Authors: Elias Botvinick; Jesse Davis; Michael Dae; John O'Connell; Norberto Schechtmann; Joseph Abbott; Fred Morady; Peter Lanzer; John Iskikian; Melvin Scheinman Journal: JACC Cardiovasc Imaging Date: 2008-09
Authors: M Rosenqvist; K Isaaz; E H Botvinick; M W Dae; J Cockrell; J A Abbott; N B Schiller; J C Griffin Journal: Am J Cardiol Date: 1991-01-15 Impact factor: 2.778
Authors: Gabe B Bleeker; Theodorus A M Kaandorp; Hildo J Lamb; Eric Boersma; Paul Steendijk; Albert de Roos; Ernst E van der Wall; Martin J Schalij; Jeroen J Bax Journal: Circulation Date: 2006-02-13 Impact factor: 29.690