Literature DB >> 19758697

Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL).

Malgorzata Labuda1, Annabel Gahier, Vincent Gagné, Albert Moghrabi, Daniel Sinnett, Maja Krajinovic.   

Abstract

Childhood acute lymphoblastic leukemia patients (n=310) were analyzed for four SNPs in the NR3C1 gene. Polymorphisms -627A/G, intron 2 +646C/G and 9bT/C were all associated with reduced event-free survival. Haplotypes composed of AGT alleles at these loci and tagged by the intron 2 +646G variant also associated with lower event-free survival (p=0.03). The progressive impact of this haplotype on outcome was seen with two copies associated with reduced overall survival (p=0.05). Quantitative mRNA analysis in lymphoblastoid cell lines showed that carriers of the AGT haplotype had a higher ratio of GR gamma/alpha isoforms (p=0.04), which possibly explains its association with reduced event-free survival and overall survival. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19758697     DOI： 10.1016/j.leukres.2009.08.007

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  9 in total

1.  MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies.

Authors:  Ronit Vogt Sionov
Journal:  ISRN Hematol       Date:  2013-01-29

2.  Diagnostic value of the dual-luciferase report assay for predicting response to glucocorticoid in children with acute lymphoblastic leukemia.

Authors:  X Wang; P Chen; Y Sun; Y Chen; M Mao; T Jiang; J Ouyang
Journal:  Clin Transl Oncol       Date:  2017-04-25       Impact factor: 3.405

3.  Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions.

Authors:  Lei Cao-Lei; Salomon Carlos Leija; Robert Kumsta; Stefan Wüst; Jobst Meyer; Jonathan D Turner; Claude P Muller
Journal:  Hum Genet       Date:  2011-01-15       Impact factor: 4.132

4.  Bim polymorphisms: influence on function and response to treatment in children with acute lymphoblastic leukemia.

Authors:  Vincent Gagné; Julie Rousseau; Malgorzata Labuda; Bahram Sharif-Askari; Ivan Brukner; Caroline Laverdière; Francesco Ceppi; Stephen E Sallan; Lewis B Silverman; Donna Neuberg; Jeffery L Kutok; Daniel Sinnett; Maja Krajinovic
Journal:  Clin Cancer Res       Date:  2013-08-01       Impact factor: 12.531

5.  ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia.

Authors:  Julie Rousseau; Vincent Gagné; Malgorzata Labuda; Cyrielle Beaubois; Daniel Sinnett; Caroline Laverdière; Albert Moghrabi; Stephen E Sallan; Lewis B Silverman; Donna Neuberg; Jeffery L Kutok; Maja Krajinovic
Journal:  Blood       Date:  2011-10-04       Impact factor: 22.113

6.  Association Between N363S and BclI Polymorphisms of the Glucocorticoid Receptor Gene (NR3C1) and Glucocorticoid Side Effects During Childhood Acute Lymphoblastic Leukemia Treatment.

Authors:  Meriç Kaymak Cihan; Halil Gürhan Karabulut; Nüket Yürür Kutlay; Hatice Ilgın Ruhi; Ajlan Tükün; Lale Olcay
Journal:  Turk J Haematol       Date:  2017-02-09       Impact factor: 1.831

7.  Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia.

Authors:  Vladimir Gasic; Branka Zukic; Biljana Stankovic; Dragana Janic; Lidija Dokmanovic; Jelena Lazic; Nada Krstovski; Vita Dolzan; Janez Jazbec; Sonja Pavlovic; Nikola Kotur
Journal:  Radiol Oncol       Date:  2018-09-11       Impact factor: 2.991

Review 8.  Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.

Authors:  Krzysztof Jędraszek; Marta Malczewska; Karolina Parysek-Wójcik; Monika Lejman
Journal:  Int J Mol Sci       Date:  2022-03-12       Impact factor: 5.923

9.  Inherited genetic variants associated with glucocorticoid sensitivity in leukaemia cells.

Authors:  Tamao Shinohara; Kevin Y Urayama; Atsushi Watanabe; Koshi Akahane; Kumiko Goi; Meixian Huang; Keiko Kagami; Masako Abe; Kanji Sugita; Yukinori Okada; Hiroaki Goto; Masayoshi Minegishi; Shotaro Iwamoto; Takeshi Inukai
Journal:  J Cell Mol Med       Date:  2020-10-01       Impact factor: 5.295
  9 in total

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