Literature DB >> 19758189

Effector functions of antiaquaporin-4 autoantibodies in neuromyelitis optica.

Romain Cayrol1, Philippe Saikali, Thierry Vincent.   

Abstract

NMO-IgG autoantibody is now considered a useful serum biomarker of neuromyelitis optica (NMO). A series of clinical and pathological observations suggest that NMO-IgG may play a central role in NMO physiopathology. Although the exact role and function of NMO-IgG in vivo remain to be determined, recent reports suggest that this antibody that targets the aquaporin-4 (AQP-4) water channel expressed by astrocytes is able to destabilize the blood-brain barrier and contribute to astrocyte and oligodendrocyte damage. This review summarizes the latest molecular effector functions attributed to the NMO-IgG/anti-AQP4 antibody and discusses their potential role in NMO pathology.

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Year:  2009        PMID： 19758189     DOI： 10.1111/j.1749-6632.2009.04871.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  9 in total

Review 1.  Immune mediated diseases and immune modulation in the neurocritical care unit.

Authors:  Gloria von Geldern; Thomas McPharlin; Kyra Becker
Journal:  Neurotherapeutics       Date:  2012-01       Impact factor: 7.620

Review 2.  [Therapeutic monoclonal antibodies in clinical neurology].

Authors:  M Buttmann; H Wiendl
Journal:  Nervenarzt       Date:  2010-06       Impact factor: 1.214

3.  Cross-immunoreactivity between bacterial aquaporin-Z and human aquaporin-4: potential relevance to neuromyelitis optica.

Authors:  Zhihua Ren; Yan Wang; Tao Duan; Jilpa Patel; Thomas Liggett; Eileah Loda; Sarang Brahma; Rajendra Goswami; Carrie Grouse; Richard Byrne; Dusan Stefoski; Adil Javed; Stephen D Miller; Roumen Balabanov
Journal:  J Immunol       Date:  2012-09-24       Impact factor: 5.422

Review 4.  Development, maintenance and disruption of the blood-brain barrier.

Authors:  Birgit Obermeier; Richard Daneman; Richard M Ransohoff
Journal:  Nat Med       Date:  2013-12-05       Impact factor: 53.440

Review 5.  Toward a new autoantibody diagnostic orthodoxy: understanding the bad, good and indifferent.

Authors:  Marvin J Fritzler
Journal:  Auto Immun Highlights       Date:  2012-03-21

6.  Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis.

Authors:  Harleen Saini; Robert Rifkin; Michael Gorelik; Hwa Huang; Zachary Ferguson; Melina V Jones; Michael Levy
Journal:  BMC Neurol       Date:  2013-08-08       Impact factor: 2.474

7.  An immunoassay that distinguishes real neuromyelitis optica signals from a labeling detected in patients receiving natalizumab.

Authors:  Ismael Sánchez Gomar; María Díaz Sánchez; Antonio José Uclés Sánchez; José Luis Casado Chocán; Reposo Ramírez-Lorca; Ana Serna; Javier Villadiego; Juan José Toledo-Aral; Miriam Echevarría
Journal:  BMC Neurol       Date:  2014-07-01       Impact factor: 2.474

Review 8.  Neurovascular unit in chronic pain.

Authors:  Beatrice Mihaela Radu; Placido Bramanti; Francesco Osculati; Maria-Luisa Flonta; Mihai Radu; Giuseppe Bertini; Paolo Francesco Fabene
Journal:  Mediators Inflamm       Date:  2013-06-05       Impact factor: 4.711

9.  Comparative Analysis for the Presence of IgG Anti-Aquaporin-1 in Patients with NMO-Spectrum Disorders.

Authors:  Ismael Sánchez Gomar; María Díaz Sánchez; Antonio José Uclés Sánchez; José Luis Casado Chocán; Nela Suárez-Luna; Reposo Ramírez-Lorca; Javier Villadiego; Juan José Toledo-Aral; Miriam Echevarría
Journal:  Int J Mol Sci       Date:  2016-07-23       Impact factor: 5.923
  9 in total

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