Literature DB >> 19757802

Solid-phase peptide synthesis in water using microwave-assisted heating.

Athanassios S Galanis1, Fernando Albericio, Morten Grøtli.   

Abstract

An approach using water as a solvent (coupling and deprotection) was developed for the solid-phase synthesis of peptides using the most common Boc-amino acid derivatives. Key aspects of this methodology are the use of a PEG-based resin, EDC-HONB as a coupling method, and microwave irradiation as an energy source.

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Year:  2009        PMID: 19757802     DOI: 10.1021/ol901893p

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  8 in total

1.  Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation.

Authors:  Michael C Pirrung; Fa Zhang; Sudhakar Ambadi; Y Gangadhara Rao
Journal:  Org Biomol Chem       Date:  2016-08-17       Impact factor: 3.876

2.  Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation.

Authors:  Nir Qvit; Opher S Kornfeld
Journal:  J Vis Exp       Date:  2016-01-26       Impact factor: 1.355

3.  A new Oxyma derivative for nonracemizable amide-forming reactions in water.

Authors:  Qinghui Wang; Yong Wang; Michio Kurosu
Journal:  Org Lett       Date:  2012-06-14       Impact factor: 6.005

Review 4.  Greening the synthesis of peptide therapeutics: an industrial perspective.

Authors:  Vincent Martin; Peter H G Egelund; Henrik Johansson; Sebastian Thordal Le Quement; Felix Wojcik; Daniel Sejer Pedersen
Journal:  RSC Adv       Date:  2020-11-24       Impact factor: 4.036

5.  Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging.

Authors:  Rüdiger Pipkorn; Manfred Wiessler; Waldemar Waldeck; Ute Hennrich; Kiyoshi Nokihara; Marcel Beining; Klaus Braun
Journal:  Int J Med Sci       Date:  2011-11-05       Impact factor: 3.738

6.  Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis.

Authors:  Ashish Kumar; Anamika Sharma; Beatriz G de la Torre; Fernando Albericio
Journal:  Molecules       Date:  2019-11-05       Impact factor: 4.411

7.  Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives.

Authors:  Srinivasa Rao Manne; Anamika Sharma; Andrius Sazonovas; Ayman El-Faham; Beatriz G de la Torre; Fernando Albericio
Journal:  ACS Omega       Date:  2022-02-09

8.  Rapid Screening of Antimicrobial Synthetic Peptides.

Authors:  Maciej Jaskiewicz; Malgorzata Orlowska; Gabriela Olizarowicz; Dorian Migon; Daria Grzywacz; Wojciech Kamysz
Journal:  Int J Pept Res Ther       Date:  2015-09-28       Impact factor: 1.931

  8 in total

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