INTRODUCTION: Prostate cancer (CaP) is one of the most important causes of morbidity and mortality in the world. There is evidence that obesity and inadequate eating habits may promote CaP development. OBJECTIVE: To analyze and compare the body mass index (BMI) and the food intake, especially fats and antioxidants, among subjects with CaP and those free of disease as a control group. MATERIAL AND METHODS: A sample of 40 men between 50 and 80 years old were selected for the study: 20 with CaP and 20 healthy men as control group. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy, and a nutritional interview where a dietary history and different anthropometric measurements were made. Statistical analysis was performed using the Student T test for independent samples (p < 0.05). RESULTS: BMI in the subjects with CaP was higher than in controls (29.8 kg/m2 vs. 27.96 kg/m2, p = 0.13) but not statistically significant. However, there was a direct correlation between BMI and tumor aggressiveness (r = 0.79, P < 0.001). Total, saturated, monounsaturated and polyunsaturated fat intake was significantly higher in subjects with CaP; while omega3 fatty acids, vitamin C and lycopene intake was significantly lower than in controls (p < 0.05). CONCLUSIONS: A healthy weight and a diet low in total fat, saturated, monounsaturated and polyunsaturated fat and rich in n3 fatty acids, vitamin C and lycopene is associated with a lower risk of CaP.
INTRODUCTION:Prostate cancer (CaP) is one of the most important causes of morbidity and mortality in the world. There is evidence that obesity and inadequate eating habits may promote CaP development. OBJECTIVE: To analyze and compare the body mass index (BMI) and the food intake, especially fats and antioxidants, among subjects with CaP and those free of disease as a control group. MATERIAL AND METHODS: A sample of 40 men between 50 and 80 years old were selected for the study: 20 with CaP and 20 healthy men as control group. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy, and a nutritional interview where a dietary history and different anthropometric measurements were made. Statistical analysis was performed using the Student T test for independent samples (p < 0.05). RESULTS: BMI in the subjects with CaP was higher than in controls (29.8 kg/m2 vs. 27.96 kg/m2, p = 0.13) but not statistically significant. However, there was a direct correlation between BMI and tumor aggressiveness (r = 0.79, P < 0.001). Total, saturated, monounsaturated and polyunsaturated fat intake was significantly higher in subjects with CaP; while omega3 fatty acids, vitamin C and lycopene intake was significantly lower than in controls (p < 0.05). CONCLUSIONS: A healthy weight and a diet low in total fat, saturated, monounsaturated and polyunsaturated fat and rich in n3 fatty acids, vitamin C and lycopene is associated with a lower risk of CaP.
Authors: Constanza M López Fontana; María E Maselli; Rafael F Pérez Elizalde; Nicolás A Di Milta Mónaco; Ana L Uvilla Recupero; José D López Laur Journal: J Physiol Biochem Date: 2011-05-11 Impact factor: 4.158
Authors: Elizabeth M Masko; Jean A Thomas; Jodi A Antonelli; Jessica C Lloyd; Tameika E Phillips; Susan H Poulton; Mark W Dewhirst; Salvatore V Pizzo; Stephen J Freedland Journal: Cancer Prev Res (Phila) Date: 2010-08-17
Authors: Nitin Shivappa; Camila Niclis; Julia Becaria Coquet; María D Román; James R Hébert; María Del Pilar Diaz Journal: Cancer Causes Control Date: 2018-07-17 Impact factor: 2.506
Authors: Michael A Liss; Osamah Al-Bayati; Jonathan Gelfond; Martin Goros; Sarah Ullevig; John DiGiovanni; Jill Hamilton-Reeves; Denise O'Keefe; Dean Bacich; Brandi Weaver; Robin Leach; Ian M Thompson Journal: Prostate Cancer Prostatic Dis Date: 2018-11-01 Impact factor: 5.554