Literature DB >> 1975761

Glycine synergistically potentiates the enhancement of LTP induced by a sulfhydryl reducing agent.

D L Tauck1, G A Ashbeck.   

Abstract

Two selective modulators of N-methyl-D-aspartate (NMDA) receptor function, dithiothreitol (DTT) and glycine, each dramatically enhanced long-term potentiation (LTP) in area CA1 of the hippocampus slice. Glycine synergistically potentiated the effect of DTT. Kynurenate, but not strychnine, antagonized the modulatory effect of glycine on LTP, while 2-amino-5-phosphonovalerate blocked LTP in all cases. Neither oxidation with 5-5-dithio-bis-2-nitrobenzoic acid nor exposure to the oxidized form of DTT had any effect on LTP. These data suggest that in vivo the reducing potential of local environments may interact with endogenous glycine to regulate NMDA receptor function.

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Year:  1990        PMID： 1975761     DOI： 10.1016/0006-8993(90)90070-r

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.

Authors:  R M Sanchez; C Wang; G Gardner; L Orlando; D L Tauck; P A Rosenberg; E Aizenman; F E Jensen
Journal:  J Neurosci       Date:  2000-03-15       Impact factor: 6.167

2.  Photolytically released nitric oxide produces a delayed but persistent suppression of LTP in area CA1 of the rat hippocampal slice.

Authors:  K P Murphy; T V Bliss
Journal:  J Physiol       Date:  1999-03-01       Impact factor: 5.182

3.  Redox modulation of synaptic responses and plasticity in rat CA1 hippocampal neurons.

Authors:  C L Bernard; J C Hirsch; R Khazipov; Y Ben-Ari; H Gozlan
Journal:  Exp Brain Res       Date:  1997-02       Impact factor: 1.972

4.  The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.

Authors:  Maede Rezaie; Mohammad Nasehi; Salar Vaseghi; Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani; Mohammad-Reza Zarrindast; Mohammad Ali Nasiri Khalili
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2020-06-24       Impact factor: 3.000

5.  The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.

Authors:  L H Tang; E Aizenman
Journal:  J Physiol       Date:  1993-06       Impact factor: 5.182

Review 6.  Mitochondria, oxidative stress, and temporal lobe epilepsy.

Authors:  Simon Waldbaum; Manisha Patel
Journal:  Epilepsy Res       Date:  2009-10-21       Impact factor: 3.045

7.  Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels.

Authors:  Marzia Martina; Yelena Gorfinkel; Samantha Halman; John A Lowe; Pranav Periyalwar; Christopher J Schmidt; Richard Bergeron
Journal:  J Physiol       Date:  2004-04-02       Impact factor: 5.182

8.  Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress.

Authors:  Ashok Kumar
Journal:  Front Aging Neurosci       Date:  2011-05-20       Impact factor: 5.750

Review 9.  Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia.

Authors:  Andrea de Bartolomeis; Mirko Manchia; Federica Marmo; Licia Vellucci; Felice Iasevoli; Annarita Barone
Journal:  Front Psychiatry       Date:  2020-05-14       Impact factor: 4.157

10.  The impact of D-cycloserine and sarcosine on in vivo frontal neural activity in a schizophrenia-like model.

Authors:  Lulu Yao; Zongliang Wang; Di Deng; Rongzhen Yan; Jun Ju; Qiang Zhou
Journal:  BMC Psychiatry       Date:  2019-10-25       Impact factor: 3.630
  10 in total

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