Literature DB >> 1975739

Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells.

S Ullrich1, M Prentki, C B Wollheim.   

Abstract

Somatostatin inhibited Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells, albeit with decreased sensitivity relative to intact cells. The inhibitory action required the presence of GTP, whereas GDP could not substitute for GTP. Pertussis-toxin treatment before cell permeabilization abolished the inhibition of secretion. Thus somatostatin, by activating a G-protein, interferes with exocytosis distal to the generation of soluble intracellular messengers.

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Year:  1990        PMID： 1975739      PMCID： PMC1131711          DOI： 10.1042/bj2700273

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores.

Authors:  T Katada; M Ui
Journal:  J Biol Chem       Date:  1979-01-25       Impact factor: 5.157

2.  Inhibition of insulin release by somatostatin: no evidence for interaction with calcium.

Authors:  C B Wollheim; B Blondel; M Kikuchi; G W Sharp
Journal:  Metabolism       Date:  1978-09       Impact factor: 8.694

Review 3.  Somatostatin (second of two parts).

Authors:  S Reichlin
Journal:  N Engl J Med       Date:  1983-12-22       Impact factor: 91.245

Review 4.  Somatostatin.

Authors:  S Reichlin
Journal:  N Engl J Med       Date:  1983-12-15       Impact factor: 91.245

5.  Rapid inhibition by somatostatin of vasoactive intestinal peptide-induced prolactin secretion by rat pituitary cells. Relationship to cyclic AMP accumulation.

Authors:  W H Rostene; M Dussaillant; G Rosselin
Journal:  FEBS Lett       Date:  1982-09-06       Impact factor: 4.124

6.  Catecholamine inhibition of Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans.

Authors:  P M Jones; J M Fyles; S J Persaud; S L Howell
Journal:  FEBS Lett       Date:  1987-07-13       Impact factor: 4.124

7.  Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture.

Authors:  C B Wollheim; M Kikuchi; A E Renold; G W Sharp
Journal:  J Clin Invest       Date:  1977-11       Impact factor: 14.808

8.  Somatostatin inhibition of glucose-induced electrical activity in cultured rat islet cells.

Authors:  C S Pace; M Murphy; S Conant; P E Lacy
Journal:  Am J Physiol       Date:  1977-11

9.  Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.

Authors:  R F Santerre; R A Cook; R M Crisel; J D Sharp; R J Schmidt; D C Williams; C P Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

10.  The regulation of extramitochondrial steady state free Ca2+ concentration by rat insulinoma mitochondria.

Authors:  M Prentki; D Janjic; C B Wollheim
Journal:  J Biol Chem       Date:  1983-06-25       Impact factor: 5.157
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  19 in total

Review 1.  Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.

Authors:  G G Holz; C A Leech; J F Habener
Journal:  Biochimie       Date:  2000 Sep-Oct       Impact factor: 4.079

2.  Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.

Authors:  R P Robertson; H J Zhang; K L Pyzdrowski; T F Walseth
Journal:  J Clin Invest       Date:  1992-08       Impact factor: 14.808

3.  Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins.

Authors:  Ying Wang; Sangeun Park; Neil S Bajpayee; Yoshiko Nagaoka; Guylain Boulay; Lutz Birnbaumer; Meisheng Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-10       Impact factor: 11.205

4.  Dynamics of Ca2+ and guanosine 5'-[gamma-thio]triphosphate action on insulin secretion from alpha-toxin-permeabilized HIT-T15 cells.

Authors:  J C Jonas; G Li; M Palmer; U Weller; C B Wollheim
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

5.  Effects of glucose, forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1.

Authors:  S Ullrich; K B Abel; S Lehr; R Greger
Journal:  Pflugers Arch       Date:  1996-08       Impact factor: 3.657

6.  Block of Ca(2+)-channels by alpha-endosulphine inhibits insulin release.

Authors:  Anne Virsolvy; Paul Smith; Gyslaine Bertrand; Laurent Gros; Lisa Héron; Guillermo Salazar; Raymond Puech; Dominique Bataille
Journal:  Br J Pharmacol       Date:  2002-04       Impact factor: 8.739

7.  Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.

Authors:  Y Okamoto; H Ishida; Y Tsuura; K Yasuda; S Kato; H Matsubara; M Nishimura; N Mizuno; H Ikeda; Y Seino
Journal:  Diabetologia       Date:  1995-07       Impact factor: 10.122

8.  Calcium currents at motor nerve endings: absence of effects of adenosine receptor agonists in the frog.

Authors:  E M Silinsky; C S Solsona
Journal:  J Physiol       Date:  1992-11       Impact factor: 5.182

9.  Masked excitatory action of noradrenaline on rat islet beta-cells via activation of phospholipase C.

Authors:  Sechiko Suga; Kyoko Nakano; Teruko Takeo; Tomohiro Osanai; Yoshiji Ogawa; Soroku Yagihashi; Takahiro Kanno; Makoto Wakui
Journal:  Pflugers Arch       Date:  2003-10-24       Impact factor: 3.657

10.  Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins.

Authors:  G Li; R Regazzi; E Roche; C B Wollheim
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857
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