BACKGROUND: In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition. MATERIALS AND METHODS: We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope. RESULTS: With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged. CONCLUSIONS: In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.
BACKGROUND: In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition. MATERIALS AND METHODS: We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope. RESULTS: With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged. CONCLUSIONS: In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.
Authors: Victoria L Cooper; Mark W Elliott; Stan B Pearson; Claire M Taylor; Roger Hainsworth Journal: Clin Auton Res Date: 2007-01-30 Impact factor: 4.435
Authors: Matthias Blüher; Stefan Engeli; Nora Klöting; Janin Berndt; Mathias Fasshauer; Sándor Bátkai; Pál Pacher; Michael R Schön; Jens Jordan; Michael Stumvoll Journal: Diabetes Date: 2006-11 Impact factor: 9.461
Authors: J A Wagner; K Hu; J Bauersachs; J Karcher; M Wiesler; S K Goparaju; G Kunos; G Ertl Journal: J Am Coll Cardiol Date: 2001-12 Impact factor: 24.094
Authors: Sándor Bátkai; Pál Pacher; Douglas Osei-Hyiaman; Svetlana Radaeva; Jie Liu; Judith Harvey-White; László Offertáler; Ken Mackie; M Audrey Rudd; Richard D Bukoski; George Kunos Journal: Circulation Date: 2004-09-27 Impact factor: 29.690
Authors: Andrea Dlugos; Emma Childs; Kara L Stuhr; Cecilia J Hillard; Harriet de Wit Journal: Neuropsychopharmacology Date: 2012-07-04 Impact factor: 7.853