[Fred Siguier (1909-1972). A Paris physician who foresaw the significance of systemic disease].

Fred Siguier was one of the first clinicians in Europe to focus on a group of rare, little known and etiologically unclear diseases, which at the time were termed collagen diseases and are today known as systemic diseases. Siguier described not only the individual disease patterns, but also transitional and mixed forms and thereby recognised their innate relationship, although the immunological background was unknown at that time. More than half a century ago, he was convinced that he was dealing with"diseases of the future". His prognosis has been confirmed on every level.