Literature DB >> 19756447

Therapeutic potential of olfactory ensheathing cells in neurodegenerative diseases.

Shao-Chih Chiu1, Huey-Shan Hung, Shinn-Zong Lin, Esheral Chiang, Demeral David Liu.   

Abstract

The regenerative capacity of the olfactory system has generated interest in potential clinical application of cells from the olfactory epithelium in the treatment of neurodegenerative diseases. Experimental evidence from animal models and clinical studies suggest that transplantation of olfactory ensheathing cells (OEC), specialized glia in the olfactory system, may be therapeutically useful in neurodegenerative diseases such as spinal cord injury and stroke. This review article describes the different experimental approaches in OEC transplantation. We also discuss the possible effects of OEC implantation on the underlying pathophysiology in neurological disease, including neuroplasticity. Our recent study of this particular population of cells has disclosed some of the molecular basis of the regenerative mechanism of OECs. In summary OECs produce several neurotrophic factors such as stromal cell-derived factor 1alpha and brain-derived neurotrophic factor and enhance axonal regeneration to promote neuroplasticity in neurodegenerative diseases.

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Year:  2009        PMID： 19756447     DOI： 10.1007/s00109-009-0528-2

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  125 in total

Review 1.  Neurotrophic factors in the primary olfactory pathway.

Authors:  A Mackay-Sima; M I Chuahb
Journal:  Prog Neurobiol       Date:  2000-12       Impact factor: 11.685

2.  The differentiation of rat adipose-derived stem cells into OEC-like cells on collagen scaffolds by co-culturing with OECs.

Authors:  Bin Wang; Jin Han; Yuan Gao; Zhifeng Xiao; Bing Chen; Xia Wang; Wenxue Zhao; Jianwu Dai
Journal:  Neurosci Lett       Date:  2007-06-02       Impact factor: 3.046

3.  The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro.

Authors:  Jana Vukovic; Marc J Ruitenberg; Kasper Roet; Elske Franssen; Ajanthy Arulpragasam; Takako Sasaki; Joost Verhaagen; Alan R Harvey; Samantha J Busfield; Giles W Plant
Journal:  Glia       Date:  2009-03       Impact factor: 7.452

4.  Plasticity of connections of the olfactory sensory neuron: regeneration into the forebrain following bulbectomy in the neonatal mouse.

Authors:  P P Graziadei; R R Levine; G A Monti Graziadei
Journal:  Neuroscience       Date:  1979       Impact factor: 3.590

5.  Alterations in expression of the neurotrophic factors glial cell line-derived neurotrophic factor, ciliary neurotrophic factor and brain-derived neurotrophic factor, in the target-deprived olfactory neuroepithelium.

Authors:  M E Buckland; A M Cunningham
Journal:  Neuroscience       Date:  1999-04       Impact factor: 3.590

6.  Mice devoid of PrP are resistant to scrapie.

Authors:  H Büeler; A Aguzzi; A Sailer; R A Greiner; P Autenried; M Aguet; C Weissmann
Journal:  Cell       Date:  1993-07-02       Impact factor: 41.582

7.  Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.

Authors:  T M DeChiara; R Vejsada; W T Poueymirou; A Acheson; C Suri; J C Conover; B Friedman; J McClain; L Pan; N Stahl; N Y Ip; G D Yancopoulos
Journal:  Cell       Date:  1995-10-20       Impact factor: 41.582

8.  Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord.

Authors:  M I Chuah; D Choi-Lundberg; S Weston; A J Vincent; R S Chung; J C Vickers; A K West
Journal:  Exp Neurol       Date:  2004-01       Impact factor: 5.330

9.  Alpha-MSH inhibits inflammatory signalling in olfactory ensheathing cells.

Authors:  Katrina A Teare; Richard G Pearson; Kevin M Shakesheff; Geoff Raisman; John W Haycock
Journal:  Neuroreport       Date:  2003-12-02       Impact factor: 1.837

10.  Rat olfactory neurons can utilize the endogenous lectin, L-14, in a novel adhesion mechanism.

Authors:  N K Mahanthappa; D N Cooper; S H Barondes; G A Schwarting
Journal:  Development       Date:  1994-06       Impact factor: 6.868
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  17 in total

1.  Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury.

Authors:  David Arboleda; Serhiy Forostyak; Pavla Jendelova; Dana Marekova; Takashi Amemori; Helena Pivonkova; Katarina Masinova; Eva Sykova
Journal:  Cell Mol Neurobiol       Date:  2011-06-01       Impact factor: 5.046

2.  Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.

Authors:  Hongyun Huang; Lin Chen; Paul Sanberg
Journal:  Cell Med       Date:  2010-01-01

Review 3.  Olfaction.

Authors:  Jayant M Pinto
Journal:  Proc Am Thorac Soc       Date:  2011-03

4.  Olfactory-ensheathing cells promote physiological repair of injured recurrent laryngeal nerves and functional recovery of glottises in dogs.

Authors:  Hongyi Liu; Yu Pu; Yaping Xu; He Xu; Huanhai Liu; Yin Cheng; Weihua Xu; Xiaoping Chen; Jingping Fan
Journal:  Mol Cell Biochem       Date:  2018-02-28       Impact factor: 3.396

Review 5.  Extracellular matrix abnormalities in schizophrenia.

Authors:  Sabina Berretta
Journal:  Neuropharmacology       Date:  2011-08-16       Impact factor: 5.250

6.  Phagocytic removal of neuronal debris by olfactory ensheathing cells enhances neuronal survival and neurite outgrowth via p38MAPK activity.

Authors:  Bao-Rong He; Song-Tao Xie; Ming-Mei Wu; Ding-Jun Hao; Hao Yang
Journal:  Mol Neurobiol       Date:  2013-11-22       Impact factor: 5.590

7.  Transplantation of olfactory ensheathing cells attenuates acute carbon monoxide poisoning-induced brain damages in rats.

Authors:  Wei Liu; Qiang Zheng; Yu Wang; Xinfei Han; Li Yuan; Min Zhao
Journal:  Neurochem Res       Date:  2014-11-05       Impact factor: 3.996

8.  Visualization of ex vivo rabbit olfactory mucosa and foramina with three-dimensional optical coherence tomography.

Authors:  Tiffany Thienthao Pham; Andrew Emon Heidari; Amir Aaron Hakimi; Yan Li; Cameron Michael Heilbronn; Ellen Minyoung Hong; Ji-Hun Mo; Edward Cheng-Lung Kuan; Zhongping Chen; Brian Jet-Fei Wong
Journal:  Lasers Med Sci       Date:  2022-07-02       Impact factor: 2.555

9.  Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model.

Authors:  Nicolas Granger; Helen Blamires; Robin J M Franklin; Nick D Jeffery
Journal:  Brain       Date:  2012-11       Impact factor: 13.501

10.  L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair.

Authors:  Li Sun; Ren Qiang; Yao Yang; Zheng-Lin Jiang; Guo-Hua Wang; Guang-Wei Zhao; Tao-Jie Ren; Rui Jiang; Li-Hua Xu
Journal:  PLoS One       Date:  2014-03-26       Impact factor: 3.240
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