Literature DB >> 19755120

Involvement of SigT and RstA in the differentiation of Streptomyces coelicolor.

Xu-Ming Mao1, Zhan Zhou, Liang-Ying Cheng, Xiao-Ping Hou, Wen-Jun Guan, Yong-Quan Li.   

Abstract

SigT is an ECF sigma factor in Streptomyces coelicolor. sigT and its putative anti-sigma factor gene rstA are located in one putative operon, and SigT could physically interact with RstA. Deletion of sigT or rstA caused accelerated morphological development and enhanced production of antibiotics, concomitant with over-expression of chpE, chpH, actII-orf4 and redD. Furthermore, SigT was undetectable after loss of rstA. These data suggested that SigT has a negative role on differentiation and that RstA negatively regulates the SigT activity through a putative antagonistic mechanism and at the post-transcriptional level.

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Year:  2009        PMID： 19755120     DOI： 10.1016/j.febslet.2009.09.025

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Activation and discovery of tsukubarubicin from Streptomyces tsukubaensis through overexpressing SARPs.

Authors:  Qing-Bin Wu; Xin-Ai Chen; Zhong-Yuan Lv; Xiao-Ying Zhang; Yu Liu; Yong-Quan Li
Journal:  Appl Microbiol Biotechnol       Date:  2021-05-22       Impact factor: 4.813

2.  Dual positive feedback regulation of protein degradation of an extra-cytoplasmic function σ factor for cell differentiation in Streptomyces coelicolor.

Authors:  Xu-Ming Mao; Ning Sun; Feng Wang; Shuai Luo; Zhan Zhou; Wei-Hong Feng; Fang-Liang Huang; Yong-Quan Li
Journal:  J Biol Chem       Date:  2013-09-06       Impact factor: 5.157

3.  WblAch, a pivotal activator of natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis L10, is positively regulated by AdpAch.

Authors:  Pin Yu; Shui-Ping Liu; Qing-Ting Bu; Zhen-Xing Zhou; Zhen-Hong Zhu; Fang-Liang Huang; Yong-Quan Li
Journal:  Appl Environ Microbiol       Date:  2014-08-29       Impact factor: 4.792

4.  FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.

Authors:  Xiao-Sheng Zhang; Hong-Dou Luo; Yang Tao; Yue-Yue Wang; Xin-Hang Jiang; Hui Jiang; Yong-Quan Li
Journal:  J Ind Microbiol Biotechnol       Date:  2016-10-18       Impact factor: 3.346

5.  Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor.

Authors:  Xu-Ming Mao; Zhi-Hao Sun; Bi-Rong Liang; Zhi-Bin Wang; Wei-Hong Feng; Fang-Liang Huang; Yong-Quan Li
Journal:  J Bacteriol       Date:  2013-03-01       Impact factor: 3.490

6.  Genome plasticity and systems evolution in Streptomyces.

Authors:  Zhan Zhou; Jianying Gu; Yong-Quan Li; Yufeng Wang
Journal:  BMC Bioinformatics       Date:  2012-06-25       Impact factor: 3.169

7.  Inference of sigma factor controlled networks by using numerical modeling applied to microarray time series data of the germinating prokaryote.

Authors:  Eva Strakova; Alice Zikova; Jiri Vohradsky
Journal:  Nucleic Acids Res       Date:  2013-10-23       Impact factor: 16.971

8.  Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2).

Authors:  Davide D'Alia; Daniela Eggle; Kay Nieselt; Wei-Shou Hu; Rainer Breitling; Eriko Takano
Journal:  Microb Biotechnol       Date:  2010-12-08       Impact factor: 5.813

9.  Bidirectional Regulation of AdpAch in Controlling the Expression of scnRI and scnRII in the Natamycin Biosynthesis of Streptomyces chattanoogensis L10.

Authors:  Pin Yu; Qing-Ting Bu; Yi-Li Tang; Xu-Ming Mao; Yong-Quan Li
Journal:  Front Microbiol       Date:  2018-03-02       Impact factor: 5.640

10.  Development of Series of Affinity Tags in Streptomyces.

Authors:  Xu-Ming Mao; Ning Sun; Yang Zheng; Yong-Quan Li
Journal:  Sci Rep       Date:  2017-07-31       Impact factor: 4.379
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