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Literature DB >> 19754482

Influence of splitting on dissolution properties of metoprolol tablets.

Abstract

The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19754482 PMCID： PMC5632511 DOI： 10.17305/bjbms.2009.2815

Source DB: PubMed Journal: Bosn J Basic Med Sci ISSN： 1512-8601 Impact factor: 3.363

12 in total

Review 1. Modeling and comparison of dissolution profiles.

Authors: P Costa; J M Sousa Lobo
Journal: Eur J Pharm Sci Date: 2001-05 Impact factor: 4.384

2. Tablet splitting: imperfect perhaps, but better than excessive dosing.

Authors: Jay S Cohen
Journal: J Am Pharm Assoc (Wash) Date: 2002 Mar-Apr

3. The practice of splitting tablets: cost and therapeutic aspects.

Authors: John Bachynsky; Cheryl Wiens; Krystal Melnychuk
Journal: Pharmacoeconomics Date: 2002 Impact factor: 4.981

4. Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets.

Authors: Susanne Muschert; Florence Siepmann; Bruno Leclercq; Brian Carlin; Juergen Siepmann
Journal: Eur J Pharm Biopharm Date: 2008-12-25 Impact factor: 5.571

Review 5. Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease.

Authors: G L Plosker; S P Clissold
Journal: Drugs Date: 1992-03 Impact factor: 9.546

6. Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.

Authors: J Godbillon; D Evard; N Vidon; M Duval; J P Schoeller; J J Bernier; J Hirtz
Journal: Br J Clin Pharmacol Date: 1985 Impact factor: 4.335

7. Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Authors: G Jobin; A Cortot; J Godbillon; M Duval; J P Schoeller; J Hirtz; J J Bernier
Journal: Br J Clin Pharmacol Date: 1985 Impact factor: 4.335

Influence of splitting on dissolution properties of metoprolol tablets.

Review 1. Modeling and comparison of dissolution profiles.

2. Tablet splitting: imperfect perhaps, but better than excessive dosing.

3. The practice of splitting tablets: cost and therapeutic aspects.

4. Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets.

Review 5. Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease.

6. Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.

7. Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

8. Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.

Review 9. Controlled release metoprolol. Clinical pharmacokinetic and therapeutic implications.

10. How to adjust desired drug release patterns from ethylcellulose-coated dosage forms.

1. Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets.