Utkan Akyol1, Metin Güngörmüş. 1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.
Abstract
BACKGROUND AND OBJECTIVE: To investigate the effect of low-level laser therapy (LLLT) on healing of skin incisions made using a diode laser in diabetic rats. MATERIAL AND METHODS: Eighteen diabetic Wistar rats were used for this study. One incision was performed on the left side of the dorsum using a diode laser, and the other two incisions were made with a scalpel and diode laser on the right side of each rat. The wound on the left side of each rat received laser stimulation (10 J/cm(2)). The rats were assigned to three experimental groups. Group 1, scalpel (n = 18); Group 2, diode (n = 18); Group 3, diode + biostimulation (n = 18). RESULTS: Reepithelialization was fastest in Group 2 than Group 1 at day 10. The difference between Groups 1 and 3 was also statistically significant in reepithelialization at day 10. There was a significant difference between Groups 1 and 2 and between Groups 2 and 3 in inflammation at day 10. There was no difference between any of the groups in inflammation and reepithelialization at day 20. CONCLUSIONS: Scalpel incisions heal more slowly than diode and diode + biostimulation incisions in diabetic rats. We can suggest that diode + biostimulation may produce the least amount of tissue injury, with the fastest resolution of inflammatory response in diabetic rats. Diode laser incision (4 W) with 10-J/cm(2) LLLT seems to have a beneficial effect on skin incisions in diabetic rats.
BACKGROUND AND OBJECTIVE: To investigate the effect of low-level laser therapy (LLLT) on healing of skin incisions made using a diode laser in diabeticrats. MATERIAL AND METHODS: Eighteen diabeticWistar rats were used for this study. One incision was performed on the left side of the dorsum using a diode laser, and the other two incisions were made with a scalpel and diode laser on the right side of each rat. The wound on the left side of each rat received laser stimulation (10 J/cm(2)). The rats were assigned to three experimental groups. Group 1, scalpel (n = 18); Group 2, diode (n = 18); Group 3, diode + biostimulation (n = 18). RESULTS: Reepithelialization was fastest in Group 2 than Group 1 at day 10. The difference between Groups 1 and 3 was also statistically significant in reepithelialization at day 10. There was a significant difference between Groups 1 and 2 and between Groups 2 and 3 in inflammation at day 10. There was no difference between any of the groups in inflammation and reepithelialization at day 20. CONCLUSIONS: Scalpel incisions heal more slowly than diode and diode + biostimulation incisions in diabeticrats. We can suggest that diode + biostimulation may produce the least amount of tissue injury, with the fastest resolution of inflammatory response in diabeticrats. Diode laser incision (4 W) with 10-J/cm(2) LLLT seems to have a beneficial effect on skin incisions in diabeticrats.
Authors: Fernando José Camello de Lima; Olavo Barbosa de Oliveira Neto; Fabiano Timbó Barbosa; Ailton Mota do Nascimento Galvão; Fernando Wagner Silva Ramos; Christiane Calheiros Farias de Lima; Célio Fernando de Sousa Rodrigues Journal: Lasers Med Sci Date: 2016-02-09 Impact factor: 3.161
Authors: Róbert Kilík; Lucia Lakyová; Ján Sabo; Peter Kruzliak; Kamila Lacjaková; Tomáš Vasilenko; Martina Vidová; František Longauer; Jozef Radoňak Journal: Biomed Res Int Date: 2014-01-16 Impact factor: 3.411