Literature DB >> 19754039

"Zipper" molecular beacons: a generalized strategy to optimize the performance of activatable protease probes.

Juan Chen1, Tracy W B Liu, Pui-Chi Lo, Brian C Wilson, Gang Zheng.   

Abstract

We report the proof-of-principle concept for zipper molecular beacons (ZMB) comprising an asymmetrical polyarginine/polyglutamate electrostatic "zipper" hairpin-linked fluorophore-quencher pair. The objective is to balance maximal quenching efficiency and optimal two-step activation (protease cleavage/zipper dissociation), while enhancing target cell uptake. This strategy also eliminates the peptide sequence dependence of conventional protease beacons. This ZMB concept is a generalizable approach to improve the functionality of a wide range of diagnostic/therapeutic probes through a simple switching of substrate sequences.

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Year:  2009        PMID： 19754039     DOI： 10.1021/bc900207k

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  8 in total

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3.  Emerging applications of porphyrins in photomedicine.

Authors:  Haoyuan Huang; Wentao Song; James Rieffel; Jonathan F Lovell
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4.  Directed evolution of protease beacons that enable sensitive detection of endogenous MT1-MMP activity in tumor cell lines.

Authors:  Abeer Jabaiah; Patrick S Daugherty
Journal:  Chem Biol       Date:  2011-03-25

5.  Activatable Optical Probes for the Detection of Enzymes.

Authors:  Christopher R Drake; David C Miller; Ella F Jones
Journal:  Curr Org Synth       Date:  2011-08       Impact factor: 1.975

6.  Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides.

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7.  Protease-activated drug development.

Authors:  Ki Young Choi; Magdalena Swierczewska; Seulki Lee; Xiaoyuan Chen
Journal:  Theranostics       Date:  2012-02-08       Impact factor: 11.556

8.  Activatable Peptides for Rapid and Simple Visualization of Protease Activity Secreted in Living Cells.

Authors:  Gae-Baik Kim; Jeong Min Lee; Duc Long Nguyen; Joonseok Lee; Young-Pil Kim
Journal:  Int J Mol Sci       Date:  2022-01-30       Impact factor: 5.923
  8 in total

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