Rong-qing Sun1, Hong-Fu Yang. 1. the First Affiliated Hospital of Zhengzhou University, Henan, China. rongqing.sun@126.com
Abstract
OBJECTIVE: To investigate the correlation of the data of patients with sepsis in intensive care unit (ICU) and their prognosis. METHODS: Clinical data of 450 cases with sepsis in ICU from January 2004 to December 2008 were retrospectively studied. Twenty-four possible prognostic factors including clinical, chemical examinations and scores contributing to the survival of these patients were analyzed with univariate and multivariate logistic regression analysis. RESULTS: Univariate logistic regression analysis: eight factors were non-risk factors for sepsis, including days of hospitalization [odds ratio (OR)=0.951, P<0.001], Glasgow coma score (GCS, OR=0.858 , P<0.001), mean arterial pressure (OR=0.991, P=0.041), platelet count (OR=0.997, P<0.001), total protein (OR=0.975,P=0.003), albumin (OR=0.955, P<0.001), arterial pH (OR=0.077,P=0.001), arterial oxygen pressure (OR=0.996, P=0.014). The risk factors for sepsis included acute physiology and chronic health evaluation II (APACHE II) score (OR=1.115, P<0.001), body temperature (OR=1.215, P=0.041), prothrombin time (OR=1.057, P=0.007), aspartate aminotransferase (OR=1.001, P=0.011), serum creatinine (OR=1.002, P=0.002), blood potassium level (OR=1.391, P=0.003), blood glucose (OR=1.051, P=0.002), and C-reactive protein (OR=1.245, P=0.001). Multivariate logistic regression analysis showed that risk factors of sepsis included APACHE II score (OR=1.094, P<0.001), days of hospitalization (OR=0.946, P<0.001), platelet count (OR=0.976, P=0.004), and albumin level (OR=0.957, P=0.017). CONCLUSION: APACHE II score, days of hospitalization, platelet count and albumin could predict the prognosis of sepsis.
OBJECTIVE: To investigate the correlation of the data of patients with sepsis in intensive care unit (ICU) and their prognosis. METHODS: Clinical data of 450 cases with sepsis in ICU from January 2004 to December 2008 were retrospectively studied. Twenty-four possible prognostic factors including clinical, chemical examinations and scores contributing to the survival of these patients were analyzed with univariate and multivariate logistic regression analysis. RESULTS: Univariate logistic regression analysis: eight factors were non-risk factors for sepsis, including days of hospitalization [odds ratio (OR)=0.951, P<0.001], Glasgow coma score (GCS, OR=0.858 , P<0.001), mean arterial pressure (OR=0.991, P=0.041), platelet count (OR=0.997, P<0.001), total protein (OR=0.975,P=0.003), albumin (OR=0.955, P<0.001), arterial pH (OR=0.077,P=0.001), arterial oxygen pressure (OR=0.996, P=0.014). The risk factors for sepsis included acute physiology and chronic health evaluation II (APACHE II) score (OR=1.115, P<0.001), body temperature (OR=1.215, P=0.041), prothrombin time (OR=1.057, P=0.007), aspartate aminotransferase (OR=1.001, P=0.011), serum creatinine (OR=1.002, P=0.002), blood potassium level (OR=1.391, P=0.003), blood glucose (OR=1.051, P=0.002), and C-reactive protein (OR=1.245, P=0.001). Multivariate logistic regression analysis showed that risk factors of sepsis included APACHE II score (OR=1.094, P<0.001), days of hospitalization (OR=0.946, P<0.001), platelet count (OR=0.976, P=0.004), and albumin level (OR=0.957, P=0.017). CONCLUSION: APACHE II score, days of hospitalization, platelet count and albumin could predict the prognosis of sepsis.