BACKGROUND: Helicobacter pylori, a known risk factor of gastric cancer, rarely colonize the deeper portion of normal gastric glands, where the mucus is rich in alpha-1,4-linked N-acetylglucosamine capped O-glycans, that strongly inhibit H. pylori growth in vitro. MATERIALS AND METHODS: We investigated the association between genetic variation in the O-glycan transferase encoding gene (a4GnT) and H. pylori infection and gastric cancer risk using a Polish population-based case-control study (273 gastric cancer patients and 377 controls). RESULTS: A haplotype at the rs2622694-rs397266 locus was associated with H. pylori infection, with the A-A haplotype associated with a higher risk compared with the most frequent G-G haplotype (odds ratio 2.30; 95% confidence interval 1.35-3.92). The association remained significant after correction for multiple tests (global p value: nominal 0.002, empirical 0.045). Neither this haplotype nor the tagSNPs were associated with overall gastric cancer risk. CONCLUSION: a4GnT genetic variation may be relevant to H. pylori infection, but not to gastric cancer risk.
BACKGROUND:Helicobacter pylori, a known risk factor of gastric cancer, rarely colonize the deeper portion of normal gastric glands, where the mucus is rich in alpha-1,4-linked N-acetylglucosamine capped O-glycans, that strongly inhibit H. pylori growth in vitro. MATERIALS AND METHODS: We investigated the association between genetic variation in the O-glycan transferase encoding gene (a4GnT) and H. pyloriinfection and gastric cancer risk using a Polish population-based case-control study (273 gastric cancerpatients and 377 controls). RESULTS: A haplotype at the rs2622694-rs397266 locus was associated with H. pyloriinfection, with the A-A haplotype associated with a higher risk compared with the most frequent G-G haplotype (odds ratio 2.30; 95% confidence interval 1.35-3.92). The association remained significant after correction for multiple tests (global p value: nominal 0.002, empirical 0.045). Neither this haplotype nor the tagSNPs were associated with overall gastric cancer risk. CONCLUSION:a4GnT genetic variation may be relevant to H. pyloriinfection, but not to gastric cancer risk.
Authors: Benjamin French; Thomas Lumley; Stephanie A Monks; Kenneth M Rice; Lucia A Hindorff; Alexander P Reiner; Bruce M Psaty Journal: Genet Epidemiol Date: 2006-09 Impact factor: 2.135
Authors: E M El-Omar; M Carrington; W H Chow; K E McColl; J H Bream; H A Young; J Herrera; J Lissowska; C C Yuan; N Rothman; G Lanyon; M Martin; J F Fraumeni; C S Rabkin Journal: Nature Date: 2000-03-23 Impact factor: 49.962
Authors: Birgitte Bertelsen; Lusine Nazaryan-Petersen; Wei Sun; Mana M Mehrjouy; Gangcai Xie; Wei Chen; Lena E Hjermind; Peter E M Taschner; Zeynep Tümer Journal: Genet Med Date: 2015-08-27 Impact factor: 8.822