| Literature DB >> 197489 |
Abstract
The newly synthesized psoralen derivatives, 4' hydroxymethyl 4,5',8 trimethylpsoralen, 4' methoxymethyl 4,5',8 trimethylpsoralen, and 4' aminomethyl 4,5',8 trimethylpsoralen hydrochloride photoreact with the single-stranded RNA animal virus, Vesicular Stomatitis virus, VSV. This virus is inactivated 10(3) times more effectively by photoreaction with these compounds than when photoreacted with 4,5',8 trimethylpsoralen. Under these conditions the RNA virus remains more than 10(3) times less sensitive to inactivation by these new photoreagents than were two double-stranded DNA viruses, Herpes Simplex type 2 (HSV-2) and Vaccinia. Preliminary evidence for the generality of this result is discussed.Entities:
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Year: 1977 PMID: 197489 PMCID: PMC343759 DOI: 10.1093/nar/4.5.1339
Source DB: PubMed Journal: Nucleic Acids Res ISSN: 0305-1048 Impact factor: 16.971