Literature DB >> 1974869

Inhibition of gamma-glutamyl transpeptidase decreases amino acid uptake in human keratinocytes in culture.

J R Viña1, P Blay, A Ramirez, A Castells, J Viña.   

Abstract

Acivicin inhibits gamma-glutamyl transpeptidase activity in human keratinocytes in culture. Treatment of these cells with acivicin produces a decrease in the uptake of L-[U-14C]alanine, 2-amino-[1-14C]-isobutyrate, L-[U-14C]leucine and 1-aminocyclopentane-1-[14C]carboxylate. D-[U-14C]glucose uptake is not affected by the presence of acivicin. These results support, for the first time in vitro, the hypothesis that the gamma-glutamyl cycle may be involved in amino acid uptake by human cells.

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Year:  1990        PMID： 1974869     DOI： 10.1016/0014-5793(90)81125-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  High-level expression of enzymatically active mature human gamma-glutamyltransferase in transgenic V79 Chinese hamster cells.

Authors:  A Visvikis; C Thioudellet; T Oster; S Fournel-Gigleux; M Wellman; G Siest
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

2.  A role for gamma-glutamyl transpeptidase and the amino acid transport system xc- in cystine transport by a human pancreatic duct cell line.

Authors:  J H Sweiry; J Sastre; J Viña; H P Elsässer; G E Mann
Journal:  J Physiol       Date:  1995-05-15       Impact factor: 5.182

3.  A comparison of membrane enzymes of human and pig oesophagus; the pig oesophagus is a good model for studies of the gullet in man.

Authors:  K N Christie; C Thomson; D Hopwood
Journal:  Histochem J       Date:  1995-03
  3 in total

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