Literature DB >> 19748552

Valproic acid as a promising agent to combat Alzheimer's disease.

Xiu-Zhen Zhang1, Xue-Juan Li, Hong-Yu Zhang.   

Abstract

Alzheimer's disease (AD) is one of the most threatening diseases to the elderly population at present. However, there is no yet efficient therapeutic method to AD. Recently, accumulating evidence indicates that valproic acid (VPA), a widely used mood stabilizer and antiepileptic drug, has neuroprotective potential relevant to AD. Moreover, VPA can induce neurogenesis of neural progenitor/stem cells both in vitro and in vivo via multiple signaling pathways. Therefore, it is suggested that VPA is a promising agent to combat AD.

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Year:  2010        PMID： 19748552     DOI： 10.1016/j.brainresbull.2009.09.003

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  20 in total

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Journal:  Epilepsy Curr       Date:  2014-03       Impact factor: 7.500

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Journal:  J Biol Chem       Date:  2010-10-20       Impact factor: 5.157

4.  Cisplatin and paclitaxel co-delivery nanosystem for ovarian cancer chemotherapy.

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Review 5.  Modeling Huntington's disease with induced pluripotent stem cells.

Authors:  Julia A Kaye; Steven Finkbeiner
Journal:  Mol Cell Neurosci       Date:  2013-02-28       Impact factor: 4.314

6.  Update on the pharmacological treatment of Alzheimer's disease.

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Journal:  Curr Neuropharmacol       Date:  2010-03       Impact factor: 7.363

7.  Effect of sodium valproate administration on brain neprilysin expression and memory in rats.

Authors:  Natalia N Nalivaeva; Nikolai D Belyaev; David I Lewis; Alasdair R Pickles; Natalia Z Makova; Daria I Bagrova; Nadezhda M Dubrovskaya; Svetlana A Plesneva; Igor A Zhuravin; Anthony J Turner
Journal:  J Mol Neurosci       Date:  2011-09-20       Impact factor: 3.444

8.  Cell wall integrity is compromised under temperature stress in Schizosaccharomyces pombe expressing a valproic acid-sensitive vas4 mutant.

Authors:  Sen Qiao; Lili Zhang; Xiaofang Luo; Hui Wang; Yue Fang
Journal:  Sci Rep       Date:  2021-06-29       Impact factor: 4.379

9.  Alternative Approaches in Gene Discovery and Characterization in Alzheimer's Disease.

Authors:  Nilüfer Ertekin-Taner; Phillip L De Jager; Lei Yu; David A Bennett
Journal:  Curr Genet Med Rep       Date:  2013-01-22

10.  Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer's disease.

Authors:  Hui Liu; Weidong Le
Journal:  Transl Neurodegener       Date:  2014-03-20       Impact factor: 8.014
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