Literature DB >> 19748335

Polyglutamine dances the conformational cha-cha-cha.

Jason Miller, Earl Rutenber, Paul J Muchowski.   

Abstract

While polyglutamine repeats appear in dozens of human proteins, high-resolution structural analysis of these repeats in their native context has eluded researchers. Kim et al. now describe multiple crystal structures and demonstrate that polyglutamine in huntingtin dances through multiple conformations.

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Year:  2009        PMID： 19748335      PMCID： PMC2830152          DOI： 10.1016/j.str.2009.08.004

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  10 in total

1.  Oligoproline effects on polyglutamine conformation and aggregation.

Authors:  Anusri Bhattacharyya; Ashwani K Thakur; Veronique M Chellgren; Geetha Thiagarajan; Angela D Williams; Brian W Chellgren; Trevor P Creamer; Ronald Wetzel
Journal:  J Mol Biol       Date:  2005-11-09       Impact factor: 5.469

2.  Flanking sequences profoundly alter polyglutamine toxicity in yeast.

Authors:  Martin L Duennwald; Smitha Jagadish; Paul J Muchowski; Susan Lindquist
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-10       Impact factor: 11.205

3.  Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.

Authors:  Justin Legleiter; Gregor P Lotz; Jason Miller; Jan Ko; Cheping Ng; Geneva L Williams; Steve Finkbeiner; Paul H Patterson; Paul J Muchowski
Journal:  J Biol Chem       Date:  2009-06-02       Impact factor: 5.157

4.  Interconversion between two unrelated protein folds in the lymphotactin native state.

Authors:  Robbyn L Tuinstra; Francis C Peterson; Snjezana Kutlesa; E Sonay Elgin; Michael A Kron; Brian F Volkman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-25       Impact factor: 11.205

5.  Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure.

Authors:  Gregory Darnell; Joseph P R O Orgel; Reinhard Pahl; Stephen C Meredith
Journal:  J Mol Biol       Date:  2007-09-14       Impact factor: 5.469

6.  Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Authors:  Randy Singh Atwal; Jianrun Xia; Deborah Pinchev; Jillian Taylor; Richard M Epand; Ray Truant
Journal:  Hum Mol Genet       Date:  2007-08-18       Impact factor: 6.150

7.  A toxic monomeric conformer of the polyglutamine protein.

Authors:  Yoshitaka Nagai; Takashi Inui; H Akiko Popiel; Nobuhiro Fujikake; Kazuhiro Hasegawa; Yoshihiro Urade; Yuji Goto; Hironobu Naiki; Tatsushi Toda
Journal:  Nat Struct Mol Biol       Date:  2007-03-18       Impact factor: 15.369

8.  Secondary structure of Huntingtin amino-terminal region.

Authors:  Mee Whi Kim; Yogarany Chelliah; Sang Woo Kim; Zbyszek Otwinowski; Ilya Bezprozvanny
Journal:  Structure       Date:  2009-09-09       Impact factor: 5.006

9.  Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.

Authors:  Jennifer L Wacker; M Hadi Zareie; Hanson Fong; Mehmet Sarikaya; Paul J Muchowski
Journal:  Nat Struct Mol Biol       Date:  2004-11-14       Impact factor: 15.369

10.  CAG-encoded polyglutamine length polymorphism in the human genome.

Authors:  Stefanie L Butland; Rebecca S Devon; Yong Huang; Carri-Lyn Mead; Alison M Meynert; Scott J Neal; Soo Sen Lee; Anna Wilkinson; George S Yang; Macaire M S Yuen; Michael R Hayden; Robert A Holt; Blair R Leavitt; B F Francis Ouellette
Journal:  BMC Genomics       Date:  2007-05-22       Impact factor: 3.969
  10 in total
  5 in total

1.  Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.

Authors:  Gregor P Lotz; Justin Legleiter; Rebecca Aron; Emily J Mitchell; Shao-Yi Huang; Cheping Ng; Charles Glabe; Leslie M Thompson; Paul J Muchowski
Journal:  J Biol Chem       Date:  2010-09-23       Impact factor: 5.157

2.  Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.

Authors:  Justin Legleiter; Emily Mitchell; Gregor P Lotz; Ellen Sapp; Cheping Ng; Marian DiFiglia; Leslie M Thompson; Paul J Muchowski
Journal:  J Biol Chem       Date:  2010-03-10       Impact factor: 5.157

Review 3.  Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.

Authors:  Adewale Adegbuyiro; Faezeh Sedighi; Albert W Pilkington; Sharon Groover; Justin Legleiter
Journal:  Biochemistry       Date:  2017-02-21       Impact factor: 3.162

4.  Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences.

Authors:  Cristina Oliva; Pedro A Sánchez-Murcia; Eva Rico; Ana Bravo; Margarita Menéndez; Federico Gago; Antonio Jiménez-Ruiz
Journal:  Nucleic Acids Res       Date:  2017-09-06       Impact factor: 16.971

5.  Structure prediction of polyglutamine disease proteins: comparison of methods.

Authors:  Jingran Wen; Daniel R Scoles; Julio C Facelli
Journal:  BMC Bioinformatics       Date:  2014-05-28       Impact factor: 3.169
  5 in total

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