Literature DB >> 19748254

Antiprotozoal activity of betulinic acid derivatives.

D B Domínguez-Carmona1, F Escalante-Erosa, K García-Sosa, G Ruiz-Pinell, D Gutierrez-Yapu, M J Chan-Bacab, A Giménez-Turba, L M Peña-Rodríguez.   

Abstract

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity. Copyright 2009 Elsevier GmbH. All rights reserved.

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Year:  2009        PMID： 19748254     DOI： 10.1016/j.phymed.2009.08.002

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  20 in total

Review 1.  Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance.

Authors:  Tanya Biswas; Upendra N Dwivedi
Journal:  Protoplasma       Date:  2019-07-11       Impact factor: 3.356

2.  Therapeutic exploration of betulinic acid in chemically induced hypothyroidism.

Authors:  Muhammad Afzal; Imran Kazmi; Susmita Semwal; Fahad A Al-Abbasi; Firoz Anwar
Journal:  Mol Cell Biochem       Date:  2013-10-05       Impact factor: 3.396

3.  Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii.

Authors:  Li Pan; Claudio M Lezama-Davila; Angelica P Isaac-Marquez; Edward P Calomeni; James R Fuchs; Abhay R Satoskar; A Douglas Kinghorn
Journal:  Phytochemistry       Date:  2012-07-26       Impact factor: 4.072

4.  Disuccinyl betulin triggers metacaspase-dependent endonuclease G-mediated cell death in unicellular protozoan parasite Leishmania donovani.

Authors:  Sayan Chowdhury; Tulika Mukherjee; Somenath Roy Chowdhury; Souvik Sengupta; Sibabrata Mukhopadhyay; Parasuraman Jaisankar; Hemanta K Majumder
Journal:  Antimicrob Agents Chemother       Date:  2014-01-27       Impact factor: 5.191

5.  Anti-Trichomonas vaginalis activity from triterpenoid derivatives.

Authors:  Adrine Maria Innocente; Patrícia de Brum Vieira; Amanda Piccoli Frasson; Bruna Bento Casanova; Grace Gosmann; Simone Cristina Baggio Gnoatto; Tiana Tasca
Journal:  Parasitol Res       Date:  2014-06-01       Impact factor: 2.289

6.  Triterpenes from Euphorbia spinidens with immunomodulatory activity.

Authors:  M Ghannadian; A Akhavan; O M Abdalla; A M Ayatollahi; M Mohammadi-Kamalabadi; H Ghazanfari
Journal:  Res Pharm Sci       Date:  2013-07

Review 7.  Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.

Authors:  Rafael Balaña-Fouce; Raquel Alvarez-Velilla; Christopher Fernández-Prada; Carlos García-Estrada; Rosa M Reguera
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-08-24       Impact factor: 4.077

8.  Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine.

Authors:  Maria C Sousa; Raquel Varandas; Rita C Santos; Manuel Santos-Rosa; Vera Alves; Jorge A R Salvador
Journal:  PLoS One       Date:  2014-03-18       Impact factor: 3.240

9.  Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity.

Authors:  Abdul Majid Ayatollahi; Mustafa Ghanadian; Suleiman Afsharypuor; M Ahmad Mesaik; Omer Mohamed Abdalla; Mohsen Shahlaei; Gholamhossein Farzandi; Hamid Mostafavi
Journal:  Iran J Pharm Res       Date:  2011       Impact factor: 1.696

10.  Evaluation of Antiplasmodial activity of extracts and constituents from Ampelozizyphus amazonicus.

Authors:  Dominique F M do Carmo; Ana Claudia F Amaral; Marta Machado; Dinora Lopes; Aurea Echevarria; Virgílio E Rosário; Jefferson Rocha de A Silva
Journal:  Pharmacogn Mag       Date:  2015-10       Impact factor: 1.085
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