| Literature DB >> 19747699 |
Luc Meva'a Mbaze1, Jean Alexandre Lado, Jean Duplex Wansi, Tze Chieh Shiao, David Dako Chiozem, Muhammad Ahmed Mesaik, Muhammad Iqbal Choudhary, Marie-Aleth Lacaille-Dubois, Jean Wandji, René Roy, Norbert Sewald.
Abstract
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC(50)=2.0-6.5 microM, but no cytotoxic effect was observed (IC(50)>100 microM).Entities:
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Year: 2009 PMID： 19747699 DOI： 10.1016/j.phytochem.2009.08.007
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072