Literature DB >> 19747151

Recent patents on the Pichia pastoris expression system: expanding the toolbox for recombinant protein production.

Monika Bollok1, David Resina, Francisco Valero, Pau Ferrer.   

Abstract

Pichia pastoris is a widely used host system for heterologous protein expression both for basic research and industrial production purposes. Recent developments expanding the P. pastoris protein expression toolbox reflect the increasing interest in the application of yeast expression systems for protein-based pharmaceutical products, as an alternative to Escherichia coli and mammalian cell factories. The commonly used expression system for P. pastoris and the recent patents relevant to the P. pastoris genetic toolbox for recombinant protein production are reviewed.

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Year:  2009        PMID: 19747151     DOI: 10.2174/187220809789389126

Source DB:  PubMed          Journal:  Recent Pat Biotechnol        ISSN: 1872-2083


  19 in total

1.  Development of quantitative metabolomics for Pichia pastoris.

Authors:  Marc Carnicer; André B Canelas; Angela Ten Pierick; Zhen Zeng; Jan van Dam; Joan Albiol; Pau Ferrer; Joseph J Heijnen; Walter van Gulik
Journal:  Metabolomics       Date:  2011-04-21       Impact factor: 4.290

2.  Recombinant Protein Production and Purification of Insoluble Proteins.

Authors:  Neus Ferrer-Miralles; Paolo Saccardo; José Luis Corchero; Elena Garcia-Fruitós
Journal:  Methods Mol Biol       Date:  2022

Review 3.  Improving industrial yeast strains: exploiting natural and artificial diversity.

Authors:  Jan Steensels; Tim Snoek; Esther Meersman; Martina Picca Nicolino; Karin Voordeckers; Kevin J Verstrepen
Journal:  FEMS Microbiol Rev       Date:  2014-05-08       Impact factor: 16.408

4.  Quantitative metabolomics analysis of amino acid metabolism in recombinant Pichia pastoris under different oxygen availability conditions.

Authors:  Marc Carnicer; Angela Ten Pierick; Jan van Dam; Joseph J Heijnen; Joan Albiol; Walter van Gulik; Pau Ferrer
Journal:  Microb Cell Fact       Date:  2012-06-15       Impact factor: 5.328

5.  Heterologous expression of the Monilinia fructicola CYP51 (MfCYP51) gene in Pichia pastoris confirms the mode of action of the novel fungicide, SYP-Z048.

Authors:  Fengping Chen; Dong Lin; Jingyuan Wang; Botao Li; Hongxia Duan; Junli Liu; Xili Liu
Journal:  Front Microbiol       Date:  2015-05-19       Impact factor: 5.640

6.  Glucose-methanol co-utilization in Pichia pastoris studied by metabolomics and instationary ¹³C flux analysis.

Authors:  Joel Jordà; Camilo Suarez; Marc Carnicer; Angela ten Pierick; Joseph J Heijnen; Walter van Gulik; Pau Ferrer; Joan Albiol; Aljoscha Wahl
Journal:  BMC Syst Biol       Date:  2013-02-28

7.  High Expression of Methylotrophic Yeast-Derived Recombinant Human Erythropoietin in a pH-Controlled Batch System.

Authors:  Ahmad Maleki; Farzin Roohvand; Hosnieh Tajerzadeh; Hossein Khanahmad; Maryam B Nobari; Ahmad Beiruti; Abdolhossein Rouholamini Najafabadi
Journal:  Avicenna J Med Biotechnol       Date:  2010-10

8.  A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut⁺/pAOX1-lacZ strain.

Authors:  Hongxing Niu; Laurent Jost; Nathalie Pirlot; Hosni Sassi; Marc Daukandt; Christian Rodriguez; Patrick Fickers
Journal:  Microb Cell Fact       Date:  2013-04-08       Impact factor: 5.328

9.  Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures.

Authors:  Joel Jordà; Paula Jouhten; Elena Cámara; Hannu Maaheimo; Joan Albiol; Pau Ferrer
Journal:  Microb Cell Fact       Date:  2012-05-08       Impact factor: 5.328

Review 10.  New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris.

Authors:  Thomas Vogl; Franz S Hartner; Anton Glieder
Journal:  Curr Opin Biotechnol       Date:  2013-03-20       Impact factor: 9.740

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