BACKGROUND: Platelet-derived growth factor (PDGF) has been shown in vivo to increase bone formation and supplement fracture healing, and may have a role as a therapeutic agent in the treatment of bone loss and fracture healing in humans. OBJECTIVE: A comprehensive review of the recent literature on the effect of PDGF on bone mineral density and fracture healing. METHODS: In vitro and in vivo evidence was systematically collected using medical search engines MEDLINE/OVID (1950 to March 2008) and EMBASE (1980 to March 2008) databases. RESULTS/ CONCLUSION: Evidence to date suggests that PDGF-BB, and to a lesser extent PDGF-AA, may have potential therapeutic use in the treatment of osteoporosis and bone healing in humans. Additionally, by targeting alpha-receptors on osteoblasts, a potential anabolic effect on bone metabolism in humans can be anticipated; however, more research needs to be done to assess the role of beta-receptors in human bone.
BACKGROUND: Platelet-derived growth factor (PDGF) has been shown in vivo to increase bone formation and supplement fracture healing, and may have a role as a therapeutic agent in the treatment of bone loss and fracture healing in humans. OBJECTIVE: A comprehensive review of the recent literature on the effect of PDGF on bone mineral density and fracture healing. METHODS: In vitro and in vivo evidence was systematically collected using medical search engines MEDLINE/OVID (1950 to March 2008) and EMBASE (1980 to March 2008) databases. RESULTS/ CONCLUSION: Evidence to date suggests that PDGF-BB, and to a lesser extent PDGF-AA, may have potential therapeutic use in the treatment of osteoporosis and bone healing in humans. Additionally, by targeting alpha-receptors on osteoblasts, a potential anabolic effect on bone metabolism in humans can be anticipated; however, more research needs to be done to assess the role of beta-receptors in human bone.
Authors: Maximilian Petri; Ali Namazian; Florian Wilke; Max Ettinger; Timo Stübig; Stephan Brand; Frank Bengel; Christian Krettek; Georg Berding; Michael Jagodzinski Journal: Int Orthop Date: 2013-09-08 Impact factor: 3.075
Authors: Ben P Hung; Daphne L Hutton; Kristen L Kozielski; Corey J Bishop; Bilal Naved; Jordan J Green; Arnold I Caplan; Jeffrey M Gimble; Amir H Dorafshar; Warren L Grayson Journal: Stem Cells Date: 2015-06-26 Impact factor: 6.277
Authors: Mauricio Kfuri; Rafael Lara de Freitas; Bruno Bellaguarda Batista; Rodrigo Salim; Marcello Teixeira Castiglia; Ricardo Antonio Tavares; Paulo Henrique Araújo Journal: Curr Rev Musculoskelet Med Date: 2014-09
Authors: Ethan L Nyberg; Ashley L Farris; Ben P Hung; Miguel Dias; Juan R Garcia; Amir H Dorafshar; Warren L Grayson Journal: Ann Biomed Eng Date: 2016-06-13 Impact factor: 3.934