Literature DB >> 19745606

Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells.

Janet Lee1, Chang Geun Lee, Kyo-Won Lee, Chang-Woo Lee.   

Abstract

BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of the chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and are linked to diseases such as cancer. Studies using BubR1 mouse models suggest that BubR1 activities prevent premature aging and infertility. In this study, we show that BubR1 depletion in human adipose-derived mesenchymal stem cells (ASCs) precedes loss of the differentiation potential and induction of replicative senescence. These effects occur independently of p16(INK4A) expression and may involve DNA methylation. Our results reveal a new and unsuspected feature of BubR1 expression in regulation of adult stem cell differentiation.

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Year:  2009        PMID： 19745606      PMCID： PMC2802683          DOI： 10.3858/emm.2009.41.12.093

Source DB:  PubMed          Journal:  Exp Mol Med        ISSN： 1226-3613            Impact factor:   8.718


  24 in total

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Authors:  Jm Gimble; F Guilak
Journal:  Cytotherapy       Date:  2003       Impact factor: 5.414

2.  Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

Authors:  Yinghui Mao; Ariane Abrieu; Don W Cleveland
Journal:  Cell       Date:  2003-07-11       Impact factor: 41.582

3.  Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.

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Journal:  Science       Date:  1997-02-28       Impact factor: 47.728

4.  Multilineage cells from human adipose tissue: implications for cell-based therapies.

Authors:  P A Zuk; M Zhu; H Mizuno; J Huang; J W Futrell; A J Katz; P Benhaim; H P Lorenz; M H Hedrick
Journal:  Tissue Eng       Date:  2001-04

5.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Authors:  G P Dimri; X Lee; G Basile; M Acosta; G Scott; C Roskelley; E E Medrano; M Linskens; I Rubelj; O Pereira-Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-26       Impact factor: 11.205

6.  Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

Authors:  Sandra Hanks; Kim Coleman; Sarah Reid; Alberto Plaja; Helen Firth; David Fitzpatrick; Alexa Kidd; Károly Méhes; Richard Nash; Nathanial Robin; Nora Shannon; John Tolmie; John Swansbury; Alexandre Irrthum; Jenny Douglas; Nazneen Rahman
Journal:  Nat Genet       Date:  2004-10-10       Impact factor: 38.330

7.  BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Authors:  Darren J Baker; Karthik B Jeganathan; J Douglas Cameron; Michael Thompson; Subhash Juneja; Alena Kopecka; Rajiv Kumar; Robert B Jenkins; Piet C de Groen; Patrick Roche; Jan M van Deursen
Journal:  Nat Genet       Date:  2004-06-20       Impact factor: 38.330

8.  Enhanced delivery efficiency of recombinant adenovirus into tumor and mesenchymal stem cells by a novel PTD.

Authors:  J-I Youn; S-H Park; H-T Jin; C-G Lee; S-H Seo; M-Y Song; C-W Lee; Y-C Sung
Journal:  Cancer Gene Ther       Date:  2008-07-04       Impact factor: 5.987

9.  Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.

Authors:  Hyun Jin Shin; Kwan Hyuck Baek; Ae Hwa Jeon; Moon Taek Park; Su Jae Lee; Chang Mo Kang; Hyun Sook Lee; Seong Ho Yoo; Doo Hyun Chung; Young Chul Sung; Frank McKeon; Chang Woo Lee
Journal:  Cancer Cell       Date:  2003-12       Impact factor: 31.743

10.  Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency.

Authors:  Wei Dai; Qi Wang; Tongyi Liu; Malisetty Swamy; Yuqiang Fang; Suqing Xie; Radma Mahmood; Yang-Ming Yang; Ming Xu; Chinthalapally V Rao
Journal:  Cancer Res       Date:  2004-01-15       Impact factor: 12.701
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  5 in total

1.  Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.

Authors:  A Fütterer; A Raya; M Llorente; J C Izpisúa-Belmonte; J L de la Pompa; P Klatt; C Martínez-A
Journal:  Cell Death Differ       Date:  2011-06-10       Impact factor: 15.828

2.  Mps1 kinase regulates tumor cell viability via its novel role in mitochondria.

Authors:  X Zhang; Y Ling; Y Guo; Y Bai; X Shi; F Gong; P Tan; Y Zhang; C Wei; X He; A Ramirez; X Liu; C Cao; H Zhong; Q Xu; R Z Ma
Journal:  Cell Death Dis       Date:  2016-07-07       Impact factor: 8.469

3.  Mitotic Kinases and p53 Signaling.

Authors:  Geun-Hyoung Ha; Eun-Kyoung Yim Breuer
Journal:  Biochem Res Int       Date:  2012-07-19

4.  Serum-mediated Activation of Bone Marrow-derived Mesenchymal Stem Cells in Ischemic Stroke Patients: A Novel Preconditioning Method.

Authors:  Gyeong Joon Moon; Yeon Hee Cho; Dong Hee Kim; Ji Hee Sung; Jeong Pyo Son; Sooyoon Kim; Jae Min Cha; Oh Young Bang
Journal:  Cell Transplant       Date:  2018-05-18       Impact factor: 4.064

5.  Proteogenomic Analysis Reveals Proteins Involved in the First Step of Adipogenesis in Human Adipose-Derived Stem Cells.

Authors:  Bernardo Bonilauri; Amanda C Camillo-Andrade; Marlon D M Santos; Juliana de S da G Fischer; Paulo C Carvalho; Bruno Dallagiovanna
Journal:  Stem Cells Int       Date:  2021-12-16       Impact factor: 5.443
  5 in total

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