BACKGROUND AND PURPOSE: The majority of pharmacological agents for stroke were developed based on the assumption that neurological deficits will be reduced upon the successful interruption of biochemical mechanisms leading to neuronal death. Despite significant evidence of preclinical efficacy, none of these agents succeeded. They either failed to demonstrate efficacy in the clinic or their development was halted for safety, strategic, or commercial reasons. SUMMARY OF REVIEW: This "neuroprotection strategy" has focused primarily on targets in the neurotoxic environment that occurs under ischemic conditions. In many cases, these agents were designed to tackle events that are known to start almost immediately after onset of ischemia, which is far before a realistic therapeutic time window opens for most, if not all, patients with stroke. In other instances, they were evaluated beyond a realistic timeframe in which one could expect significant salvageable tissue or penumbra to exist. Surprisingly, most of these agents were not evaluated in conjunction with strategies for improving perfusion to the affected tissue, indicating an overoptimistic assumption that neuroprotection alone could be sufficient to halt injury caused by an abrupt interruption of brain blood flow. CONCLUSIONS: We provide a constructive translational medicine perspective about how one could improve the drug development process with the hope that the probability for success can increase in our quest to establish a novel therapy for stroke.
BACKGROUND AND PURPOSE: The majority of pharmacological agents for stroke were developed based on the assumption that neurological deficits will be reduced upon the successful interruption of biochemical mechanisms leading to neuronal death. Despite significant evidence of preclinical efficacy, none of these agents succeeded. They either failed to demonstrate efficacy in the clinic or their development was halted for safety, strategic, or commercial reasons. SUMMARY OF REVIEW: This "neuroprotection strategy" has focused primarily on targets in the neurotoxic environment that occurs under ischemic conditions. In many cases, these agents were designed to tackle events that are known to start almost immediately after onset of ischemia, which is far before a realistic therapeutic time window opens for most, if not all, patients with stroke. In other instances, they were evaluated beyond a realistic timeframe in which one could expect significant salvageable tissue or penumbra to exist. Surprisingly, most of these agents were not evaluated in conjunction with strategies for improving perfusion to the affected tissue, indicating an overoptimistic assumption that neuroprotection alone could be sufficient to halt injury caused by an abrupt interruption of brain blood flow. CONCLUSIONS: We provide a constructive translational medicine perspective about how one could improve the drug development process with the hope that the probability for success can increase in our quest to establish a novel therapy for stroke.
Authors: Maria Carolina O Rodrigues; Dmitriy Dmitriev; Antonio Rodrigues; Loren E Glover; Paul R Sanberg; Julie G Allickson; Nicole Kuzmin-Nichols; Naoki Tajiri; Kazutaka Shinozuka; Svitlana Garbuzova-Davis; Yuji Kaneko; Cesar V Borlongan Journal: Interv Med Appl Sci Date: 2012-06
Authors: Veronica Go; Bethany G E Bowley; Monica A Pessina; Zheng Gang Zhang; Michael Chopp; Seth P Finklestein; Douglas L Rosene; Maria Medalla; Benjamin Buller; Tara L Moore Journal: Geroscience Date: 2019-11-06 Impact factor: 7.713
Authors: Maria Medalla; Wayne Chang; Samantha M Calderazzo; Veronica Go; Alexandra Tsolias; Joseph W Goodliffe; Dhruba Pathak; Diego De Alba; Monica Pessina; Douglas L Rosene; Benjamin Buller; Tara L Moore Journal: J Neurosci Date: 2020-04-02 Impact factor: 6.167