| Literature DB >> 19744707 |
Abdalla Awidi1, Isam I Salem, Naji Najib, Razan Mefleh, Bothainah Tarawneh.
Abstract
The aims of this study were to validate and compare HPLC and LCMSMS analytical methods and their applicability for the quantitation of imatinib in human plasma. A total of 50 patients with chronic myeloid leukemia (CML) in chronic phase (CP) receiving 400 mg/day imatinib were enrolled in the study. Drug levels were determined by HPLC-UV and LCMSMS. HPLC intra-day accuracy ranged from 100.51 to 103.19%. LCMSMS accuracy ranged from 89.72 to 106.29%. The correlation coefficient between both methods was r(2)=0.96. HPLC can be used for imatinib levels' determinations in patients accurately and precisely. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19744707 DOI： 10.1016/j.leukres.2009.08.005
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156