BACKGROUND: Environmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans. OBJECTIVE: To examine the relationship between blood metal concentrations at delivery and placenta MAO activity. METHODS: The study was performed in 163 pregnancies. Maternal and cord blood samples were obtained for manganese (Mn), lead (Pb), and cadmium (Cd) determination. Mercury (Hg) was also analysed in maternal hair. Placental samples were stored immediately after expulsion and total MAO activity was measured. RESULTS: MAO activity was significantly positively correlated with maternal and cord blood Mn concentrations in subjects with high MAO activity. In subjects with low MAO activity, maternal hair Hg was negatively correlated with MAO. CONCLUSION: Our results suggest the use of placental MAO as a potential surrogate marker of Mn toxicity in the newborn and its correlation with psychomotor development should be further investigated. Crown Copyright (c) 2009. Published by Elsevier Inc. All rights reserved.
BACKGROUND: Environmental prenatal exposure to potentially neurotoxicmetals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans. OBJECTIVE: To examine the relationship between blood metal concentrations at delivery and placenta MAO activity. METHODS: The study was performed in 163 pregnancies. Maternal and cord blood samples were obtained for manganese (Mn), lead (Pb), and cadmium (Cd) determination. Mercury (Hg) was also analysed in maternal hair. Placental samples were stored immediately after expulsion and total MAO activity was measured. RESULTS: MAO activity was significantly positively correlated with maternal and cord blood Mn concentrations in subjects with high MAO activity. In subjects with low MAO activity, maternal hair Hg was negatively correlated with MAO. CONCLUSION: Our results suggest the use of placental MAO as a potential surrogate marker of Mn toxicity in the newborn and its correlation with psychomotor development should be further investigated. Crown Copyright (c) 2009. Published by Elsevier Inc. All rights reserved.
Authors: Ana M Mora; Berna van Wendel de Joode; Donna Mergler; Leonel Córdoba; Camilo Cano; Rosario Quesada; Donald R Smith; José A Menezes-Filho; Thomas Lundh; Christian H Lindh; Asa Bradman; Brenda Eskenazi Journal: Environ Sci Technol Date: 2014-03-06 Impact factor: 9.028
Authors: Birgit Claus Henn; David C Bellinger; Marianne R Hopkins; Brent A Coull; Adrienne S Ettinger; Rebecca Jim; Earl Hatley; David C Christiani; Robert O Wright Journal: Environ Health Perspect Date: 2017-06-28 Impact factor: 9.031
Authors: Mohammad H Rahbar; Maureen Samms-Vaughan; Aisha S Dickerson; Manouchehr Hessabi; Jan Bressler; Charlene Coore Desai; Sydonnie Shakespeare-Pellington; Jody-Ann Reece; Renee Morgan; Katherine A Loveland; Megan L Grove; Eric Boerwinkle Journal: Int J Environ Res Public Health Date: 2015-04-23 Impact factor: 3.390