PURPOSE OF REVIEW: To review the efficacy of dietary protein supplementation in attenuating muscle atrophy in cachexia. RECENT FINDINGS: Only very few recent randomized controlled trials have studied the effects of protein supplementation in clinical cachexia. It appears that supplementation of dietary protein (>1.5 g/kg per day) alone or in combination with other anabolic stimuli such as exercise training maintains or even improves muscle mass, but results on muscle function are controversial and no clinical studies have yet directly linked alterations in cellular signaling or metabolic signatures of protein intake-induced muscle anabolism to muscle weight gain. SUMMARY: To elucidate the role of dietary protein supplementation in attenuating muscle atrophy in cachectic patients, randomized clinical trials are needed in adequately phenotyped patients using sensitive measures of muscle mass and function.
PURPOSE OF REVIEW: To review the efficacy of dietary protein supplementation in attenuating muscle atrophy in cachexia. RECENT FINDINGS: Only very few recent randomized controlled trials have studied the effects of protein supplementation in clinical cachexia. It appears that supplementation of dietary protein (>1.5 g/kg per day) alone or in combination with other anabolic stimuli such as exercise training maintains or even improves muscle mass, but results on muscle function are controversial and no clinical studies have yet directly linked alterations in cellular signaling or metabolic signatures of protein intake-induced muscle anabolism to muscle weight gain. SUMMARY: To elucidate the role of dietary protein supplementation in attenuating muscle atrophy in cachectic patients, randomized clinical trials are needed in adequately phenotyped patients using sensitive measures of muscle mass and function.
Authors: François Maltais; Marc Decramer; Richard Casaburi; Esther Barreiro; Yan Burelle; Richard Debigaré; P N Richard Dekhuijzen; Frits Franssen; Ghislaine Gayan-Ramirez; Joaquim Gea; Harry R Gosker; Rik Gosselink; Maurice Hayot; Sabah N A Hussain; Wim Janssens; Micheal I Polkey; Josep Roca; Didier Saey; Annemie M W J Schols; Martijn A Spruit; Michael Steiner; Tanja Taivassalo; Thierry Troosters; Ioannis Vogiatzis; Peter D Wagner Journal: Am J Respir Crit Care Med Date: 2014-05-01 Impact factor: 21.405
Authors: Derek LeRoith; Geert Jan Biessels; Susan S Braithwaite; Felipe F Casanueva; Boris Draznin; Jeffrey B Halter; Irl B Hirsch; Marie E McDonnell; Mark E Molitch; M Hassan Murad; Alan J Sinclair Journal: J Clin Endocrinol Metab Date: 2019-05-01 Impact factor: 5.958
Authors: Anna V Donaldson; Matthew Maddocks; Dario Martolini; Michael I Polkey; William D-C Man Journal: Int J Chron Obstruct Pulmon Dis Date: 2012-08-17
Authors: Céline M H Op den Kamp; Dirk K M De Ruysscher; Marieke van den Heuvel; Meike Elferink; Ruud M A Houben; Cary J G Oberije; Gerben P Bootsma; Wiel H Geraedts; Cordula C M Pitz; Ramon C Langen; Emiel F M Wouters; Annemie M W J Schols; Anne-Marie C Dingemans Journal: J Cachexia Sarcopenia Muscle Date: 2014-01-23 Impact factor: 12.910
Authors: David Pj van Dijk; Marcel Cg van de Poll; Alastair Gw Moses; Thomas Preston; Steven Wm Olde Damink; Sander S Rensen; Nicolaas Ep Deutz; Peter B Soeters; James A Ross; Kenneth Ch Fearon; Cornelis Hc Dejong Journal: J Cachexia Sarcopenia Muscle Date: 2015-04-20 Impact factor: 12.910