PURPOSE: Contrast detection is commonly measured clinically; however, discrimination between contrasts is also important for natural vision. Furthermore, optimal performance requires the visual system to adapt to ambient contrast conditions. Recent studies of primate neurophysiology demonstrate significant retinal involvement in contrast adaptation. This study was conducted to investigate whether glaucoma alters contrast adaptation. Both detection and discrimination task performance were examined. METHODS: Psychophysical contrast detection and discrimination thresholds were measured in central vision, for a vertically oriented D6 centered on 3 cyc/deg. Thresholds were measured with and without adaptation to low (15%)- and high (70%)-contrast, vertically oriented, 3-cyc/deg sinusoidal gratings. Fifteen people with glaucoma, and 15 age-similar control subjects participated. Full-contrast discrimination (dipper) functions were measured for a subset (three patients with glaucoma and three control subjects). RESULTS: On average, the glaucoma group showed elevated detection and discrimination thresholds relative to control subjects (detection: t(28) = 2.42; P = 0.02; discrimination: F(1,28) = 6.157, P = 0.02). For the subset of additionally tested participants, normalized contrast discrimination functions were similarly shaped for all observers. Glaucoma group thresholds were less influenced by contrast adaptation than were control subjects, for discrimination (F(1,28) = 10.89, P < 0.01) but not detection (F(1,28) = 2.28; P = 0.11). Differences between groups were greatest for low-contrast stimuli (significant interaction between contrast and group: P < 0.01). CONCLUSIONS: Glaucoma alters the effect of contrast adaptation on discrimination performance, particularly at low contrast. The study of suprathreshold aspects of vision may reveal new insights into the pathophysiology of glaucoma and possibly relate better to real-world visual performance than detection measures.
PURPOSE: Contrast detection is commonly measured clinically; however, discrimination between contrasts is also important for natural vision. Furthermore, optimal performance requires the visual system to adapt to ambient contrast conditions. Recent studies of primate neurophysiology demonstrate significant retinal involvement in contrast adaptation. This study was conducted to investigate whether glaucoma alters contrast adaptation. Both detection and discrimination task performance were examined. METHODS: Psychophysical contrast detection and discrimination thresholds were measured in central vision, for a vertically oriented D6 centered on 3 cyc/deg. Thresholds were measured with and without adaptation to low (15%)- and high (70%)-contrast, vertically oriented, 3-cyc/deg sinusoidal gratings. Fifteen people with glaucoma, and 15 age-similar control subjects participated. Full-contrast discrimination (dipper) functions were measured for a subset (three patients with glaucoma and three control subjects). RESULTS: On average, the glaucoma group showed elevated detection and discrimination thresholds relative to control subjects (detection: t(28) = 2.42; P = 0.02; discrimination: F(1,28) = 6.157, P = 0.02). For the subset of additionally tested participants, normalized contrast discrimination functions were similarly shaped for all observers. Glaucoma group thresholds were less influenced by contrast adaptation than were control subjects, for discrimination (F(1,28) = 10.89, P < 0.01) but not detection (F(1,28) = 2.28; P = 0.11). Differences between groups were greatest for low-contrast stimuli (significant interaction between contrast and group: P < 0.01). CONCLUSIONS:Glaucoma alters the effect of contrast adaptation on discrimination performance, particularly at low contrast. The study of suprathreshold aspects of vision may reveal new insights into the pathophysiology of glaucoma and possibly relate better to real-world visual performance than detection measures.
Authors: Anna Y M Wang; Vickie H Y Wong; Pei Ying Lee; Bang V Bui; Stefanie Dudczig; Kirstan A Vessey; Erica L Fletcher Journal: Sci Rep Date: 2021-02-18 Impact factor: 4.379