Literature DB >> 197399

Inhibition of rabbit skeletal muscle phosphorylase phosphatase by spermine.

C Nakai, W Glinsmann.   

Abstract

The effect of three naturally occurring polyamines (putrescine, spermidine, and spermine) on the activity of rabbit skeletal muscle phosphorylase phosphatase was investigated. Only spermine significantly inhibited the enzyme. The mode of inhibition (ki value of 0.3 mM) of the phosphatase by spermine appears to be different from that caused by divalent metal ions or by other organic cations, such as arginine and lysine esters, since it is noncompetitive with respect to the substrate, phosphorylase a.

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Year:  1977        PMID： 197399     DOI： 10.1007/bf01793336

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  8 in total

1.  Inhibition of the phosphorylase-rupturing enzyme by some trypsin substrates.

Authors:  P J KELLER; M FRIED
Journal:  J Biol Chem       Date:  1955-05       Impact factor: 5.157

2.  Specificity studies on muscle phosphorylase phosphatase.

Authors:  D J GRAVES; E H FISCHER; E G KREBS
Journal:  J Biol Chem       Date:  1960-03       Impact factor: 5.157

3.  The phosphorylase b to a converting enzyme of rabbit skeletal muscle.

Authors:  E G KREBS; E H FISCHER
Journal:  Biochim Biophys Acta       Date:  1956-04

4.  The isolation and crystallization of rabbit skeletal muscle phosphorylase b.

Authors:  E H FISCHER; E G KREBS
Journal:  J Biol Chem       Date:  1958-03       Impact factor: 5.157

5.  Kinetic studies of the inhibition of muscle phosphorylase phosphatase.

Authors:  T M Martensen; J E Brotherton; D J Graves
Journal:  J Biol Chem       Date:  1973-12-25       Impact factor: 5.157

6.  Glycogen synthetase-D phosphatase. I. Some new properties of the partially purified enzyme from rabbit skeletal muscle.

Authors:  K Kato; J S Bishop
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

7.  Properties of a phosphoprotein phosphatase from bovine heart with activity on glycogen synthase, phosphorylase, and histone.

Authors:  C Nakai; J A Thomas
Journal:  J Biol Chem       Date:  1974-10-25       Impact factor: 5.157

8.  Effect of polyamines on glycogen phosphorylase. Differential electrostatic interactions and enzymic properties.

Authors:  J H Wang; P M Humniski; W J Black
Journal:  Biochemistry       Date:  1968-06       Impact factor: 3.162
  8 in total

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