Literature DB >> 1973914

Structural analysis of human thyroid hormone receptor beta gene.

A Sakurai1, A Nakai, L J DeGroot.   

Abstract

Thyroid hormone receptors (TR) are ligand-dependent, DNA-binding, trans-acting transcriptional factors belonging to the erbA-related steroid/thyroid hormone receptor superfamily. To better understand the structural and functional characteristics of TRs, we isolated the gene encoding human TR beta 1 (hTR beta 1). The coding region of hTR beta 1 is split into at least eight exons. Each exon well correlates with functional domains of hTR beta 1 protein, and the exon/intron organization is highly conserved when compared with the chicken c-erbA gene which encodes an alpha-type chicken TR. We demonstrate that hTR beta has at least two mRNA forms having different lengths of the 3' untranslated region. We also note several nucleotide corrections of hTR beta 1 cDNA sequence.

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Year:  1990        PMID： 1973914     DOI： 10.1016/0303-7207(90)90245-4

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  17 in total

1.  Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells.

Authors:  Keiko Nakano; Akio Matsushita; Shigekazu Sasaki; Hiroko Misawa; Kozo Nishiyama; Yumiko Kashiwabara; Hirotoshi Nakamura
Journal:  Biochem J       Date:  2004-03-01       Impact factor: 3.857

2.  Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain.

Authors:  R Parrilla; A J Mixson; J A McPherson; J H McClaskey; B D Weintraub
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

Review 3.  Nomenclature of thyroid hormone receptor beta gene mutations in resistance to thyroid hormone. First workshop on thyroid hormone resistance, July 10-11, 1993, Cambridge, U.K.

Authors:  P Beck-Peccoz; V K Chatterjee; W W Chin; L J DeGroot; J L Jameson; H Nakamura; S Refetoff; S J Usala; B D Weintraub
Journal:  J Endocrinol Invest       Date:  1994-04       Impact factor: 4.256

4.  A novel missense mutation in the thyroid hormone receptor beta gene in a kindred with resistance to thyroid hormone.

Authors:  H Kijima; M Kubo; T Ishizuka; M Kakinuma; T Koike
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

5.  Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.

Authors:  E D Abel; M E Boers; C Pazos-Moura; E Moura; H Kaulbach; M Zakaria; B Lowell; S Radovick; M C Liberman; F Wondisford
Journal:  J Clin Invest       Date:  1999-08       Impact factor: 14.808

6.  Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo.

Authors:  D J Bradley; H C Towle; W S Young
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

7.  Detection of a new de novo mutation at codon 251 of exon 8 of thyroid hormone receptor beta gene in an Italian kindred with resistance to thyroid hormone.

Authors:  E Macchia; M Agostini; G Sarkissian; G Giorgilli; D Canale; G Scartabelli; A Margotat; J Torresani; A Pinchera
Journal:  J Endocrinol Invest       Date:  1998-04       Impact factor: 4.256

8.  A novel 1297-1304delGCCTGCCA mutation in the exon 10 of the thyroid hormone receptor β gene causes resistance to thyroid hormone.

Authors:  Carina M Rivolta; M Susana Mallea Gil; Carolina Ballarino; M Carolina Ridruejo; Carlos M Miguel; Silvia B Gimenez; Silvia S Bernacchi; Héctor M Targovnik
Journal:  Mol Diagn       Date:  2004-09

9.  Quantitation of beta 1 triiodothyronine receptor mRNA in human tissues by competitive reverse transcription polymerase chain reaction.

Authors:  S Meier-Heusler; A Pernin; H Liang; M O Goumaz; A G Burger; C A Meier
Journal:  J Endocrinol Invest       Date:  1995-11       Impact factor: 4.256

10.  Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.

Authors:  M Adams; C Matthews; T N Collingwood; Y Tone; P Beck-Peccoz; K K Chatterjee
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808
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