Literature DB >> 1973889

Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis.

A Plaitakis1.   

Abstract

Recent studies provided evidence for a generalized defect in glutamate metabolism in patients with amyotrophic lateral sclerosis, associated with widespread alterations in the central nervous system levels of this excitatory amino acid putative transmitter. Present data support the hypothesis that altered presynaptic glutamatergic mechanisms may be responsible for a neuroexcitotoxic cell loss in this disorder. High local concentrations of glycine, released from glycinergic terminals, may disrupt adaptive processes contributing to abnormal potentiation of excitatory transmission mediated by glutamate receptors and resultant selective degeneration of motor neurons. These considerations offer new therapeutic strategies for amyotrophic lateral sclerosis.

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Year:  1990        PMID： 1973889     DOI： 10.1002/ana.410280103

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  27 in total

Review 1.  Inhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis.

Authors:  Lee J Martin; Qing Chang
Journal:  Mol Neurobiol       Date:  2011-11-10       Impact factor: 5.590

2.  Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis.

Authors:  N K Gonatas; A Stieber; Z Mourelatos; Y Chen; J O Gonatas; S H Appel; A P Hays; W F Hickey; J J Hauw
Journal:  Am J Pathol       Date:  1992-03       Impact factor: 4.307

3.  Riluzole does not have an acute effect on motor thresholds and the intracortical excitability in amyotrophic lateral sclerosis.

Authors:  M Sommer; F Tergau; S Wischer; C D Reimers; W Beuche; W Paulus
Journal:  J Neurol       Date:  1999-11       Impact factor: 4.849

4.  Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis.

Authors:  Qing Chang; Lee J Martin
Journal:  J Neurosci       Date:  2011-02-23       Impact factor: 6.167

Review 5.  Amyotrophic lateral sclerosis: current and future treatment strategies.

Authors:  B W Festoff
Journal:  Drugs       Date:  1996-01       Impact factor: 9.546

6.  δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.

Authors:  Jianfeng Liang; Dongman Chao; Harleen K Sandhu; Yanbing Yu; Li Zhang; Gianfranco Balboni; Dong H Kim; Ying Xia
Journal:  Br J Pharmacol       Date:  2014-12       Impact factor: 8.739

Review 7.  Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.

Authors:  Paul C Trippier; Kristin Jansen Labby; Dustin D Hawker; Jan J Mataka; Richard B Silverman
Journal:  J Med Chem       Date:  2013-03-27       Impact factor: 7.446

8.  Lactate dehydrogenase and glutamate dehydrogenase activities in the circumventricular organs of rat brain following neonatal monosodium glutamate.

Authors:  M Bawari; G N Babu; M M Ali; U K Misra; S V Chandra
Journal:  Experientia       Date:  1993-12-15

9.  Compartmentalization of excitatory amino acid receptors in human striatum.

Authors:  L S Dure; A B Young; J B Penney
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

10.  Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

Authors:  P Gregor; R H Reeves; E W Jabs; X Yang; W Dackowski; J M Rochelle; R H Brown; J L Haines; B F O'Hara; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205
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