PURPOSE: To report long-term rates of tumor control after radiotherapy (RT) for carcinoma in situ (CIS) of the true vocal cords (TVC). MATERIALS AND METHODS: Thirty-seven patients with CIS of the TVC were treated curatively with megavoltage RT between July 1967 and December 2005. Most patients (28/37) were treated with cobalt-60; the remainder were treated with 2- to 6-MV photons. Small (usually 5 x 5) fields were used. Median RT dose was 60.0 Gy (range, 56.25-66.50 Gy; mean dose, 59.55 Gy) at 2.25 Gy per fraction. Approximately two-thirds of the patients (23/37) were referred for RT because of a recurrence after at least 1 stripping procedure. RESULTS: With a mean follow-up of 9.5 years (range, 2-25 years), the 5-year rates of local control, local control with larynx preservation, and ultimate local control (including salvage surgery) were 91%, 91%, and 91%, respectively. Invasive squamous cell carcinoma developed in 4 patients (11%). Time to failure was 6 months, 12 months, 48 months, and 13 years. Two patients were surgically salvaged with a total laryngectomy, 1 with transoral laser excision, and 1 patient declined further treatment. Cause-specific survival at 5 years was 100%. No late complications were noted. CONCLUSIONS: RT to approximately 63 Gy at 2.25 Gy per fraction, using small (5 x 5 cm) fields produces excellent results in patients with CIS of the TVC.
PURPOSE: To report long-term rates of tumor control after radiotherapy (RT) for carcinoma in situ (CIS) of the true vocal cords (TVC). MATERIALS AND METHODS: Thirty-seven patients with CIS of the TVC were treated curatively with megavoltage RT between July 1967 and December 2005. Most patients (28/37) were treated with cobalt-60; the remainder were treated with 2- to 6-MV photons. Small (usually 5 x 5) fields were used. Median RT dose was 60.0 Gy (range, 56.25-66.50 Gy; mean dose, 59.55 Gy) at 2.25 Gy per fraction. Approximately two-thirds of the patients (23/37) were referred for RT because of a recurrence after at least 1 stripping procedure. RESULTS: With a mean follow-up of 9.5 years (range, 2-25 years), the 5-year rates of local control, local control with larynx preservation, and ultimate local control (including salvage surgery) were 91%, 91%, and 91%, respectively. Invasive squamous cell carcinoma developed in 4 patients (11%). Time to failure was 6 months, 12 months, 48 months, and 13 years. Two patients were surgically salvaged with a total laryngectomy, 1 with transoral laser excision, and 1 patient declined further treatment. Cause-specific survival at 5 years was 100%. No late complications were noted. CONCLUSIONS: RT to approximately 63 Gy at 2.25 Gy per fraction, using small (5 x 5 cm) fields produces excellent results in patients with CIS of the TVC.
Authors: B G Salas-Salas; D J Domínguez-Nuez; R Cabrera; L Ferrera-Alayón; M Lloret; P C Lara Journal: Clin Transl Oncol Date: 2019-06-01 Impact factor: 3.405
Authors: Rebecca D Chernock; Brian Nussenbaum; Wade L Thorstad; Yuling Luo; Xiao-Jun Ma; Samir K El-Mofty; James S Lewis Journal: Head Neck Pathol Date: 2013-10-23
Authors: William A Stokes; Diana Abbott; Andy Phan; David Raben; Ryan M Lanning; Sana D Karam Journal: Int J Radiat Oncol Biol Phys Date: 2017-04-06 Impact factor: 7.038