| Literature DB >> 19737558 |
H Roa1, C Gajardo, E Troncoso, V Fuentealba, C Escudero, A Yáñez, L Sobrevia, M Pastor-Anglada, C Quezada, R San Martin.
Abstract
Up regulation of the transforming growth factor-beta 1 (TGF-beta1) axis has been recognized as a pathogenic event for progression of glomerulosclerosis in diabetic nephropathy. We demonstrate that glomeruli isolated from diabetic rats accumulate up to sixfold more extracellular adenosine than normal rats. Both decreased nucleoside uptake activity by the equilibrative nucleoside transporter 1 and increased AMP hydrolysis contribute to raise extracellular adenosine. Ex vivo assays indicate that activation of the low affinity adenosine A2B receptor subtype (A2BAR) mediates TGF-beta1 release from glomeruli of diabetic rats, a pathogenic event that could support progression of glomerulopathy when the bioavailability of adenosine is increased.Entities:
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Year: 2009 PMID： 19737558 DOI： 10.1016/j.febslet.2009.09.003
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124