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Literature DB >> 19737512

IKKepsilon: a bridge between obesity and inflammation.

Abstract

Obesity leads to tissue inflammation and insulin resistance, which are features of metabolic diseases such as type 2 diabetes. Chiang et al. (2009) now show that the IkappaB kinase IKKepsilon is an important link between obesity and inflammation and may be a new therapeutic target for treating obesity-related metabolic diseases.

Entities: Disease Gene

Mesh：

Substances：
I-kappa B Kinase

Year: 2009 PMID： 19737512 DOI： 10.1016/j.cell.2009.08.018

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

16 in total

1. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats.

Authors: Swarup K Chakrabarti; Yeshao Wen; Anca D Dobrian; Banumathi K Cole; Qian Ma; Hong Pei; Michael D Williams; Melissa H Bevard; George E Vandenhoff; Susanna R Keller; Jiali Gu; Jerry L Nadler
Journal: Am J Physiol Endocrinol Metab Date: 2010-10-26 Impact factor: 4.310

2. Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling.

Authors: Grant D Foglesong; Nicholas J Queen; Wei Huang; Kyle J Widstrom; Lei Cao
Journal: Endocr Relat Cancer Date: 2019-05 Impact factor: 5.678

3. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes.

Authors: Kitt Falk Petersen; Sylvie Dufour; Katsutaro Morino; Peter S Yoo; Gary W Cline; Gerald I Shulman
Journal: Proc Natl Acad Sci U S A Date: 2012-04-30 Impact factor: 11.205

4. Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.

Authors: Changtao Jiang; Jung-Hwan Kim; Fei Li; Aijuan Qu; Oksana Gavrilova; Yatrik M Shah; Frank J Gonzalez
Journal: J Biol Chem Date: 2012-12-19 Impact factor: 5.157

5. Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-κB modulation in the human gut.

Authors: Omar Lakhdari; Antonietta Cultrone; Julien Tap; Karine Gloux; Françoise Bernard; S Dusko Ehrlich; Fabrice Lefèvre; Joël Doré; Hervé M Blottière
Journal: PLoS One Date: 2010-09-30 Impact factor: 3.240

IKKepsilon: a bridge between obesity and inflammation.

1. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats.

2. Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling.

3. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes.

4. Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.

5. Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-κB modulation in the human gut.

6. Anti-inflammatory nutrition as a pharmacological approach to treat obesity.

7. IKKε knockout prevents high fat diet induced arterial atherosclerosis and NF-κB signaling in mice.

8. Maternal undernutrition and cardiometabolic disease: a Latin American perspective.

9. The A2b adenosine receptor modulates glucose homeostasis and obesity.

Review 10. Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome.