Literature DB >> 19736974

Carbon nanotubes activate blood platelets by inducing extracellular Ca2+ influx sensitive to calcium entry inhibitors.

Jana Semberova1, Silvia H De Paoli Lacerda, Olga Simakova, Karel Holada, Monique P Gelderman, Jan Simak.   

Abstract

To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63.

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Year:  2009        PMID： 19736974     DOI： 10.1021/nl901603k

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  12 in total

1.  Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome.

Authors:  Silvia H De Paoli; Tseday Z Tegegn; Oumsalama K Elhelu; Michael B Strader; Mehulkumar Patel; Lukas L Diduch; Ivan D Tarandovskiy; Yong Wu; Jiwen Zheng; Mikhail V Ovanesov; Abdu Alayash; Jan Simak
Journal:  Cell Mol Life Sci       Date:  2018-02-09       Impact factor: 9.261

2.  Determinants of the thrombogenic potential of multiwalled carbon nanotubes.

Authors:  Andrew R Burke; Ravi N Singh; David L Carroll; John D Owen; Nancy D Kock; Ralph D'Agostino; Frank M Torti; Suzy V Torti
Journal:  Biomaterials       Date:  2011-06-12       Impact factor: 12.479

3.  Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro.

Authors:  Marina A Dobrovolskaia; Anil K Patri; Jan Simak; Jennifer B Hall; Jana Semberova; Silvia H De Paoli Lacerda; Scott E McNeil
Journal:  Mol Pharm       Date:  2011-11-10       Impact factor: 4.939

Review 4.  Implantable nanosensors: toward continuous physiologic monitoring.

Authors:  Timothy T Ruckh; Heather A Clark
Journal:  Anal Chem       Date:  2013-12-10       Impact factor: 6.986

Review 5.  Nanoparticles and the blood coagulation system. Part II: safety concerns.

Authors:  Anna N Ilinskaya; Marina A Dobrovolskaia
Journal:  Nanomedicine (Lond)       Date:  2013-06       Impact factor: 5.307

Review 6.  Carbon nanotubes in hyperthermia therapy.

Authors:  Ravi Singh; Suzy V Torti
Journal:  Adv Drug Deliv Rev       Date:  2013-08-08       Impact factor: 15.470

7.  Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation.

Authors:  Jie Meng; Xuelian Cheng; Jian Liu; Weiqi Zhang; Xiaojin Li; Hua Kong; Haiyan Xu
Journal:  PLoS One       Date:  2012-07-10       Impact factor: 3.240

8.  Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets.

Authors:  Tseday Z Tegegn; Silvia H De Paoli; Martina Orecna; Oumsalama K Elhelu; Samuel A Woodle; Ivan D Tarandovskiy; Mikhail V Ovanesov; Jan Simak
Journal:  J Extracell Vesicles       Date:  2016-05-04

9.  Interaction of graphene nanoribbons with components of the blood vascular system.

Authors:  Sayan Mullick Chowdhury; Justin Fang; Balaji Sitharaman
Journal:  Future Sci OA       Date:  2015-06-02

10.  Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage.

Authors:  Akhilesh K Gaharwar; Reginald K Avery; Alexander Assmann; Arghya Paul; Gareth H McKinley; Ali Khademhosseini; Bradley D Olsen
Journal:  ACS Nano       Date:  2014-10-08       Impact factor: 15.881
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