| Literature DB >> 19736917 |
Abstract
A convergent synthesis of brevisamide (1) is described based on the application of the crotyl silane-based [4 + 2]-annulation used for the preparation of the advanced oxygenated tetrahydropyran intermediate 2. The side chain bearing a conjugated (E,E)-diene was efficiently constructed under modified Negishi cross-coupling conditions.Entities:
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Year: 2009 PMID： 19736917 DOI： 10.1021/ol901801h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005