Literature DB >> 19736621

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.

Justin E Jones1, Corey P Causey, Bryan Knuckley, Jessica L Slack-Noyes, Paul R Thompson.   

Abstract

The protein arginine deiminases (PADs), and in particular PAD4, have emerged as potential therapeutic targets for the treatment of rheumatoid arthritis (RA). In this review, evidence linking dysregulated PAD activity to the onset and progression of RA is presented, and the potential role of such aberrant activity in other human diseases, such as multiple sclerosis and cancer, is discussed. The known physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.

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Year:  2009        PMID： 19736621      PMCID： PMC3771078     

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  59 in total

1.  Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages.

Authors:  H Asaga; M Yamada; T Senshu
Journal:  Biochem Biophys Res Commun       Date:  1998-02-24       Impact factor: 3.575

2.  Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3).

Authors:  K Nakashima; T Hagiwara; A Ishigami; S Nagata; H Asaga; M Kuramoto; T Senshu; M Yamada
Journal:  J Biol Chem       Date:  1999-09-24       Impact factor: 5.157

3.  Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.

Authors:  G A Schellekens; B A de Jong; F H van den Hoogen; L B van de Putte; W J van Venrooij
Journal:  J Clin Invest       Date:  1998-01-01       Impact factor: 14.808

4.  Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.

Authors:  Akari Suzuki; Ryo Yamada; Xiaotian Chang; Shinya Tokuhiro; Tetsuji Sawada; Masakatsu Suzuki; Miyuki Nagasaki; Makiko Nakayama-Hamada; Reimi Kawaida; Mitsuru Ono; Masahiko Ohtsuki; Hidehiko Furukawa; Shinichi Yoshino; Masao Yukioka; Shigeto Tohma; Tsukasa Matsubara; Shigeyuki Wakitani; Ryota Teshima; Yuichi Nishioka; Akihiro Sekine; Aritoshi Iida; Atsushi Takahashi; Tatsuhiko Tsunoda; Yusuke Nakamura; Kazuhiko Yamamoto
Journal:  Nat Genet       Date:  2003-08       Impact factor: 38.330

5.  Histone deimination antagonizes arginine methylation.

Authors:  Graeme L Cuthbert; Sylvain Daujat; Andrew W Snowden; Hediye Erdjument-Bromage; Teruki Hagiwara; Michiyuki Yamada; Robert Schneider; Philip D Gregory; Paul Tempst; Andrew J Bannister; Tony Kouzarides
Journal:  Cell       Date:  2004-09-03       Impact factor: 41.582

6.  Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule.

Authors:  Jonathan A Hill; Scott Southwood; Alessandro Sette; Anthony M Jevnikar; David A Bell; Ewa Cairns
Journal:  J Immunol       Date:  2003-07-15       Impact factor: 5.422

7.  Structural basis for Ca(2+)-induced activation of human PAD4.

Authors:  Kyouhei Arita; Hiroshi Hashimoto; Toshiyuki Shimizu; Katsuhiko Nakashima; Michiyuki Yamada; Mamoru Sato
Journal:  Nat Struct Mol Biol       Date:  2004-07-11       Impact factor: 15.369

8.  Human PAD4 regulates histone arginine methylation levels via demethylimination.

Authors:  Yanming Wang; Joanna Wysocka; Joyce Sayegh; Young-Ho Lee; Julie R Perlin; Lauriebeth Leonelli; Lakshmi S Sonbuchner; Charles H McDonald; Richard G Cook; Yali Dou; Robert G Roeder; Steven Clarke; Michael R Stallcup; C David Allis; Scott A Coonrod
Journal:  Science       Date:  2004-09-02       Impact factor: 47.728

9.  Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein.

Authors:  D D Wood; J M Bilbao; P O'Connors; M A Moscarello
Journal:  Ann Neurol       Date:  1996-07       Impact factor: 10.422

10.  A novel microtubule independent effect of paclitaxel: the inhibition of peptidylarginine deiminase from bovine brain.

Authors:  L B Pritzker; M A Moscarello
Journal:  Biochim Biophys Acta       Date:  1998-10-14
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  101 in total

1.  Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases.

Authors:  Marie-Claire Méchin; Fanny Coudane; Véronique Adoue; Jacques Arnaud; Hélène Duplan; Marie Charveron; Anne-Marie Schmitt; Hidenari Takahara; Guy Serre; Michel Simon
Journal:  Cell Mol Life Sci       Date:  2010-01-29       Impact factor: 9.261

Review 2.  The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Authors:  Anthony R Cyr; Frederick E Domann
Journal:  Antioxid Redox Signal       Date:  2011-02-05       Impact factor: 8.401

3.  Activity-based protein profiling of protein arginine methyltransferase 1.

Authors:  Obiamaka Obianyo; Corey P Causey; Justin E Jones; Paul R Thompson
Journal:  ACS Chem Biol       Date:  2011-08-23       Impact factor: 5.100

4.  Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.

Authors:  Justin E Jones; Jessica L Slack; Pengfei Fang; Xuesen Zhang; Venkataraman Subramanian; Corey P Causey; Scott A Coonrod; Min Guo; Paul R Thompson
Journal:  ACS Chem Biol       Date:  2011-10-21       Impact factor: 5.100

5.  Photochemical Control of Protein Arginine Deiminase (PAD) Activity.

Authors:  Santanu Mondal; Sangram S Parelkar; Mitesh Nagar; Paul R Thompson
Journal:  ACS Chem Biol       Date:  2018-03-16       Impact factor: 5.100

6.  Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.

Authors:  Kevin L Bicker; Venkataraman Subramanian; Alexander A Chumanevich; Lorne J Hofseth; Paul R Thompson
Journal:  J Am Chem Soc       Date:  2012-10-03       Impact factor: 15.419

7.  Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.

Authors:  Bryan Knuckley; Corey P Causey; Perry J Pellechia; Paul F Cook; Paul R Thompson
Journal:  Chembiochem       Date:  2010-01-25       Impact factor: 3.164

8.  D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

Authors:  Kevin L Bicker; Lynne Anguish; Alexander A Chumanevich; Michael D Cameron; Xiangli Cui; Erin Witalison; Venkataraman Subramanian; Xuesen Zhang; Alena P Chumanevich; Lorne J Hofseth; Scott A Coonrod; Paul R Thompson
Journal:  ACS Med Chem Lett       Date:  2012-10-26       Impact factor: 4.345

9.  Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model.

Authors:  Bethany M Biron; Chun-Shiang Chung; Xian M O'Brien; Yaping Chen; Jonathan S Reichner; Alfred Ayala
Journal:  J Innate Immun       Date:  2016-09-14       Impact factor: 7.349

10.  NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.

Authors:  Ritika Khandpur; Carmelo Carmona-Rivera; Anuradha Vivekanandan-Giri; Alison Gizinski; Srilakshmi Yalavarthi; Jason S Knight; Sean Friday; Sam Li; Rajiv M Patel; Venkataraman Subramanian; Paul Thompson; Pojen Chen; David A Fox; Subramaniam Pennathur; Mariana J Kaplan
Journal:  Sci Transl Med       Date:  2013-03-27       Impact factor: 17.956
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