Literature DB >> 19736306

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.

Diana Romero1, Aleksandra Terzic, Barbara A Conley, Clarissa S Craft, Borko Jovanovic, Raymond C Bergan, Calvin P H Vary.   

Abstract

Endoglin, a transmembrane glycoprotein that acts as a transforming growth factor-beta (TGF-beta) coreceptor, is downregulated in PC3-M metastatic prostate cancer cells. When restored, endoglin expression in PC3-M cells inhibits cell migration in vitro and attenuates the tumorigenicity of PC3-M cells in SCID mice, though the mechanism of endoglin regulation of migration in prostate cancer cells is not known. The current study indicates that endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK2 and ALK5 in prostate cancer cells. Importantly, in the presence of constitutively active ALK2, endoglin did not inhibit cell migration, suggesting that endoglin phosphorylation regulated PC3-M cell migration. Therefore, our results suggest that endoglin phosphorylation is a mechanism with relevant functional consequences in prostate cancer cells. These data demonstrate for the first time that TGF-beta receptor-mediated phosphorylation of endoglin is a Smad-independent mechanism involved in the regulation of prostate cancer cell migration.

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Year:  2009        PMID： 19736306      PMCID： PMC2832542          DOI： 10.1093/carcin/bgp217

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  37 in total

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  15 in total

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Journal:  Cancer Res       Date:  2011-03-28       Impact factor: 12.701

Review 2.  [Value of biomarkers in urology].

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Journal:  Urologe A       Date:  2010-04       Impact factor: 0.639

Review 3.  Prostate cancer: the need for biomarkers and new therapeutic targets.

Authors:  Juliana Felgueiras; Joana Vieira Silva; Margarida Fardilha
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4.  BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.

Authors:  Kira Young; Barbara Conley; Diana Romero; Eric Tweedie; Christine O'Neill; Ilka Pinz; Louise Brogan; Volkhard Lindner; Lucy Liaw; Calvin P H Vary
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Review 5.  The role of endoglin and its soluble form in pathogenesis of preeclampsia.

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6.  Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia.

Authors:  Christine W Duarte; Kimberly Murray; F Lee Lucas; Kathleen Fairfield; Heather Miller; Peter Brooks; Calvin P H Vary
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7.  Small bowel adenocarcinoma arising in a patient with hereditary hemorrhagic telangiectasia: A case report.

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8.  The role of the 3'UTR region in the regulation of the ACVR1/Alk-2 gene expression.

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9.  Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors.

Authors:  Michael J Breen; Diarmuid M Moran; Wenzhe Liu; Xiaoke Huang; Calvin P H Vary; Raymond C Bergan
Journal:  PLoS One       Date:  2013-08-13       Impact factor: 3.240

Review 10.  TGF-β cascade regulation by PPP1 and its interactors -impact on prostate cancer development and therapy.

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Journal:  J Cell Mol Med       Date:  2014-03-15       Impact factor: 5.310
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