| Literature DB >> 1973551 |
H C Van der Gaag1, A A Axelrad.
Abstract
Young adult C57BL/6 mice are resistant to the replication of Friend virus. We show here that this resistance is not absolute. In 7-week old C57BL/6 mice injected with NB-tropic Friend virus iv, high titers of SFFV could be recovered from the spleen at 8 days after infection but by 21 days, no virus was detectable. A single dose of anti-Thy 1.2 monoclonal antibody iv before FV infection permitted continued replication of SFFV in these animals. This finding strongly supports the hypothesis that SFFV replication in C57BL/6 mice is restricted by a T cell-mediated immune response.Entities:
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Year: 1990 PMID: 1973551 DOI: 10.1016/0042-6822(90)90561-5
Source DB: PubMed Journal: Virology ISSN: 0042-6822 Impact factor: 3.616