Alexis R Frydenberg1, Stephen M Graham. 1. Department of General Medicine, Royal Children's Hospital, Melbourne, Vict., Australia. lexi.frydenberg@rch.org.au
Abstract
OBJECTIVE: To determine the frequency and manifestations of adverse events associated with recommended first-line anti-TB drugs in children. METHOD: Literature review. RESULTS: Overall, children tolerate anti-TB drugs very well when using currently recommended dosages. Serious adverse events are rare and even mild symptoms such as nausea or vomiting are uncommon. There are occasional case reports of severe hepatotoxicity. CONCLUSIONS: Surveillance and reporting of adverse events will need to be improved when recommended dosages of the main first-line anti-TB therapy for children are increased. Co-morbidities such as HIV infection and severe malnutrition may affect the incidence and complicate the management of possible adverse events to anti-TB therapy.
OBJECTIVE: To determine the frequency and manifestations of adverse events associated with recommended first-line anti-TB drugs in children. METHOD: Literature review. RESULTS: Overall, children tolerate anti-TB drugs very well when using currently recommended dosages. Serious adverse events are rare and even mild symptoms such as nausea or vomiting are uncommon. There are occasional case reports of severe hepatotoxicity. CONCLUSIONS: Surveillance and reporting of adverse events will need to be improved when recommended dosages of the main first-line anti-TB therapy for children are increased. Co-morbidities such as HIV infection and severe malnutrition may affect the incidence and complicate the management of possible adverse events to anti-TB therapy.
Authors: Andreas Sandgren; Luis E Cuevas; Masoud Dara; Robert P Gie; Malgorzata Grzemska; Anthony Hawkridge; Anneke C Hesseling; Beate Kampmann; Christian Lienhardt; Davide Manissero; Claire Wingfield; Stephen M Graham Journal: Eur Respir J Date: 2012-02-15 Impact factor: 16.671
Authors: Merrin E Rutherford; Rovina Ruslami; Winni Maharani; Indria Yulita; Sarah Lovell; Reinout Van Crevel; Bachti Alisjahbana; Philip C Hill Journal: BMC Res Notes Date: 2012-01-06
Authors: Guilherme Felipe Dos Santos Fernandes; Paula Carolina de Souza; Elsa Moreno-Viguri; Mery Santivañez-Veliz; Rocio Paucar; Silvia Pérez-Silanes; Konstantin Chegaev; Stefano Guglielmo; Loretta Lazzarato; Roberta Fruttero; Chung Man Chin; Patricia Bento da Silva; Marlus Chorilli; Mariana Cristina Solcia; Camila Maríngolo Ribeiro; Caio Sander Paiva Silva; Leonardo Biancolino Marino; Priscila Longhin Bosquesi; Debbie M Hunt; Luiz Pedro S de Carvalho; Carlos Alberto de Souza Costa; Sang Hyun Cho; Yuehong Wang; Scott Gary Franzblau; Fernando Rogério Pavan; Jean Leandro Dos Santos Journal: J Med Chem Date: 2017-10-16 Impact factor: 7.446