Literature DB >> 19734235

Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype.

José C Crispín1, George C Tsokos.   

Abstract

The origin and function of human double negative (DN) TCR-alphabeta+ T cells is unknown. They are thought to contribute to the pathogenesis of systemic lupus erythematosus because they expand and accumulate in inflamed organs. In this study, we provide evidence that human TCR-alphabeta+ CD4- CD8- DN T cells can derive from activated CD8+ T cells. Freshly isolated TCR-alphabeta+ DN T cells display a distinct gene expression and cytokine production profile. DN cells isolated from peripheral blood as well as DN cells derived in vitro from CD8+ T cells produce a defined array of proinflammatory mediators that includes IL-1beta, IL-17, IFN-gamma, CXCL3, and CXCL2. These results indicate that, upon activation, CD8+ T cells have the capacity to acquire a distinct phenotype that grants them inflammatory capacity.

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Year:  2009        PMID： 19734235      PMCID： PMC2878279          DOI： 10.4049/jimmunol.0901533

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  34 in total

1.  Fas ligand expression and function in systemic lupus erythematosus.

Authors:  J McNally; D H Yoo; J Drappa; J L Chu; H Yagita; S M Friedman; K B Elkon
Journal:  J Immunol       Date:  1997-11-01       Impact factor: 5.422

2.  Unique phenotype and distinct TCR V beta repertoire in human peripheral blood alpha beta TCR+, CD4-, and CD8- double negative T cells.

Authors:  T Niehues; B Gulwani-Akolkar; P N Akolkar; W Tax; J Silver
Journal:  J Immunol       Date:  1994-02-01       Impact factor: 5.422

3.  TCR ligation on CD8+ T cells creates double-negative cells in vivo.

Authors:  W Z Mehal; I N Crispe
Journal:  J Immunol       Date:  1998-08-15       Impact factor: 5.422

4.  A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

Authors:  M C Sneller; S E Straus; E S Jaffe; J S Jaffe; T A Fleisher; M Stetler-Stevenson; W Strober
Journal:  J Clin Invest       Date:  1992-08       Impact factor: 14.808

5.  Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells.

Authors:  E G Brooks; S P Balk; K Aupeix; M Colonna; J L Strominger; V Groh-Spies
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

6.  Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.

Authors:  M Adachi; S Suematsu; T Kondo; J Ogasawara; T Tanaka; N Yoshida; S Nagata
Journal:  Nat Genet       Date:  1995-11       Impact factor: 38.330

7.  In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cells.

Authors:  Y Laouar; S Ezine
Journal:  J Immunol       Date:  1994-11-01       Impact factor: 5.422

8.  Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene.

Authors:  D M Hammond; P S Nagarkatti; L R Goté; A Seth; M R Hassuneh; M Nagarkatti
Journal:  J Exp Med       Date:  1993-12-01       Impact factor: 14.307

9.  Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.

Authors:  L Llorente; W Zou; Y Levy; Y Richaud-Patin; J Wijdenes; J Alcocer-Varela; B Morel-Fourrier; J C Brouet; D Alarcon-Segovia; P Galanaud; D Emilie
Journal:  J Exp Med       Date:  1995-03-01       Impact factor: 14.307

10.  Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

Authors:  S Porcelli; C E Yockey; M B Brenner; S P Balk
Journal:  J Exp Med       Date:  1993-07-01       Impact factor: 14.307
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  68 in total

Review 1.  T cells as therapeutic targets in SLE.

Authors:  José C Crispín; Vasileios C Kyttaris; Cox Terhorst; George C Tsokos
Journal:  Nat Rev Rheumatol       Date:  2010-05-11       Impact factor: 20.543

Review 2.  Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions.

Authors:  Stephen C Juvet; Li Zhang
Journal:  J Mol Cell Biol       Date:  2012-02       Impact factor: 6.216

3.  Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.

Authors:  Hiroshi Kato; Andras Perl
Journal:  J Immunol       Date:  2014-03-28       Impact factor: 5.422

4.  Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus.

Authors:  Katalin Kis-Toth; Denis Comte; Maria P Karampetsou; Vasileios C Kyttaris; Lakshmi Kannan; Cox Terhorst; George C Tsokos
Journal:  Arthritis Rheumatol       Date:  2016-01       Impact factor: 10.995

5.  IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

Authors:  Masayuki Mizui; Tomohiro Koga; Linda A Lieberman; Jessica Beltran; Nobuya Yoshida; Mark C Johnson; Roland Tisch; George C Tsokos
Journal:  J Immunol       Date:  2014-07-25       Impact factor: 5.422

6.  Elevated double negative T cells in pediatric autoimmunity.

Authors:  James A Tarbox; Molly P Keppel; Nermina Topcagic; Charles Mackin; Miriam Ben Abdallah; Kevin W Baszis; Andrew J White; Anthony R French; Megan A Cooper
Journal:  J Clin Immunol       Date:  2014-04-24       Impact factor: 8.317

7.  CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.

Authors:  Carol Vinton; Nichole R Klatt; Levelle D Harris; Judith A Briant; Brigitte E Sanders-Beer; Richard Herbert; Ruth Woodward; Guido Silvestri; Ivona Pandrea; Cristian Apetrei; Vanessa M Hirsch; Jason M Brenchley
Journal:  J Virol       Date:  2011-06-29       Impact factor: 5.103

8.  cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.

Authors:  Christian M Hedrich; Thomas Rauen; Jose C Crispin; Tomohiro Koga; Christina Ioannidis; Melissa Zajdel; Vasileios C Kyttaris; George C Tsokos
Journal:  J Biol Chem       Date:  2013-09-18       Impact factor: 5.157

Review 9.  IL-17 in systemic lupus erythematosus.

Authors:  José C Crispín; George C Tsokos
Journal:  J Biomed Biotechnol       Date:  2010-04-06

10.  Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus.

Authors:  Sebastian Dolff; Daniel Quandt; Benjamin Wilde; Thorsten Feldkamp; Fan Hua; Xin Cai; Christof Specker; Andreas Kribben; Cees G M Kallenberg; Oliver Witzke
Journal:  Arthritis Res Ther       Date:  2010-07-23       Impact factor: 5.156
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