AIMS: Despite the large number of suicides that occur with intoxication, little is known about the unique predictors of suicide after alcohol consumption. The goal of this study was to examine clinical and genetic risk factors for alcohol-related suicide. METHODS: Data on 162 suicide victims were obtained from post-mortem examinations, police and prosecution inquiries, autopsy protocols and available medical records. Four single nucleotide polymorphisms in the central serotonin system and the renin-angiotensin system related genes previously found to be associated with suicide, alcohol dependence or depression were genotyped. RESULTS: The strongest predictor of suicide under the influence of alcohol was alcohol dependence (OR = 4.63). Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene. CONCLUSIONS: Suicide under the influence of alcohol is strongly connected with alcohol dependence. The TPH2 gene may play an important role in suicide vulnerability especially in individuals who did not drink alcohol before suicide.
AIMS: Despite the large number of suicides that occur with intoxication, little is known about the unique predictors of suicide after alcohol consumption. The goal of this study was to examine clinical and genetic risk factors for alcohol-related suicide. METHODS: Data on 162 suicide victims were obtained from post-mortem examinations, police and prosecution inquiries, autopsy protocols and available medical records. Four single nucleotide polymorphisms in the central serotonin system and the renin-angiotensin system related genes previously found to be associated with suicide, alcohol dependence or depression were genotyped. RESULTS: The strongest predictor of suicide under the influence of alcohol was alcohol dependence (OR = 4.63). Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene. CONCLUSIONS: Suicide under the influence of alcohol is strongly connected with alcohol dependence. The TPH2 gene may play an important role in suicide vulnerability especially in individuals who did not drink alcohol before suicide.
Authors: S Walitza; T J Renner; A Dempfle; K Konrad; Ch Wewetzer; A Halbach; B Herpertz-Dahlmann; H Remschmidt; J Smidt; M Linder; L Flierl; U Knölker; S Friedel; H Schäfer; C Gross; J Hebebrand; A Warnke; K P Lesch Journal: Mol Psychiatry Date: 2005-12 Impact factor: 15.992
Authors: Robert R Althoff; James J Hudziak; Gonneke Willemsen; Vicenta Hudziak; Meike Bartels; Dorret I Boomsma Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2011-12-07 Impact factor: 3.568
Authors: Anna Klimkiewicz; Mark A Ilgen; Amy S B Bohnert; Andrzej Jakubczyk; Marcin Wojnar; Kirk J Brower Journal: Alcohol Alcohol Date: 2012-06-12 Impact factor: 2.826
Authors: Andrea Vereczkei; Csaba Barta; Anna Magi; Judit Farkas; Andrea Eisinger; Orsolya Király; Andrea Belik; Mark D Griffiths; Anna Szekely; Mária Sasvári-Székely; Róbert Urbán; Marc N Potenza; Rajendra D Badgaiyan; Kenneth Blum; Zsolt Demetrovics; Eszter Kotyuk Journal: J Pers Med Date: 2022-04-26
Authors: Izabela Chojnicka; Sylwia Fudalej; Anna Walczak; Krystyna Wasilewska; Marcin Fudalej; Piotr Stawiński; Katarzyna Strawa; Aleksandra Pawlak; Marcin Wojnar; Paweł Krajewski; Rafał Płoski Journal: PLoS One Date: 2014-09-29 Impact factor: 3.240