Literature DB >> 19734096

Virulence and drug resistance in malaria parasites.

Wilfred D Stein1, Cecilia P Sanchez, Michael Lanzer.   

Abstract

Virulence and drug resistance are traits that pathogens can acquire independently, albeit these traits can influence each other. A recent publication has reported on the co-evolution of virulence and pyrimethamine resistance in malaria parasites. Here, we discuss this finding in the context of the folate biosynthesis pathway and explain how mutational changes in this pathway can affect both parasite replication rates and the development of drug resistance.

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Year:  2009        PMID： 19734096     DOI： 10.1016/j.pt.2009.07.003

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  6 in total

1.  Genome-wide identification and functional annotation of Plasmodium falciparum long noncoding RNAs from RNA-seq data.

Authors:  Qi Liao; Jia Shen; Jianfa Liu; Xi Sun; Guoguang Zhao; Yanzi Chang; Leiting Xu; Xuerong Li; Ya Zhao; Huanqin Zheng; Yi Zhao; Zhongdao Wu
Journal:  Parasitol Res       Date:  2014-02-13       Impact factor: 2.289

2.  Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi.

Authors:  Petra Schneider; Andrew S Bell; Derek G Sim; Aidan J O'Donnell; Simon Blanford; Krijn P Paaijmans; Andrew F Read; Sarah E Reece
Journal:  Proc Biol Sci       Date:  2012-09-26       Impact factor: 5.349

3.  Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.

Authors:  Francis W Muregi; Isao Ohta; Uchijima Masato; Hideto Kino; Akira Ishih
Journal:  PLoS One       Date:  2011-06-16       Impact factor: 3.240

4.  Fitness cost of resistance for lumefantrine and piperaquine-resistant Plasmodium berghei in a mouse model.

Authors:  Winnie R Gimode; Daniel M Kiboi; Francis T Kimani; Hannah N Wamakima; Marion W Burugu; Francis W Muregi
Journal:  Malar J       Date:  2015-01-28       Impact factor: 2.979

5.  A Synergistic Transcriptional Regulation of Olfactory Genes Drives Blood-Feeding Associated Complex Behavioral Responses in the Mosquito Anopheles culicifacies.

Authors:  Tanwee Das De; Tina Thomas; Sonia Verma; Deepak Singla; Charu Chauhan; Vartika Srivastava; Punita Sharma; Seena Kumari; Sanjay Tevatiya; Jyoti Rani; Yasha Hasija; Kailash C Pandey; Rajnikant Dixit
Journal:  Front Physiol       Date:  2018-05-23       Impact factor: 4.566

6.  A global view of the nonprotein-coding transcriptome in Plasmodium falciparum.

Authors:  Carsten A Raabe; Cecilia P Sanchez; Gerrit Randau; Thomas Robeck; Boris V Skryabin; Suresh V Chinni; Michael Kube; Richard Reinhardt; Guey Hooi Ng; Ravichandran Manickam; Vladimir Y Kuryshev; Michael Lanzer; Juergen Brosius; Thean Hock Tang; Timofey S Rozhdestvensky
Journal:  Nucleic Acids Res       Date:  2009-10-28       Impact factor: 16.971
  6 in total

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